Opana ER

Opana ER treats moderate to severe pain for those who need pain medication around the clock. Do not drink alcohol while taking this medication.

Opana ER Overview


Opana ER is a prescription medication used to treat moderate to severe pain. Opana ER belongs to a group of drugs called called opiate (narcotic) analgesics. These work by changing the way the body responds to pain.

This medication comes in an extended release tablet form and is taken every 12 hours (twice daily). It is taken on an empty stomach, at least 1 hour before or 2 hours after meals. 

Do not crush, chew, or break tablets. Swallow Opana ER tablets whole. 

Common side effects include constipation, nausea, and headache.

Opana ER can also cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you.

The FDA has requested the removal of Opana ER from the market due to the risk of abuse. 

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Opana ER Cautionary Labels




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Opana ER Drug Class

Opana ER is part of the drug class:

Opana ER FDA Warning


OPANA ER contains oxymorphone, which is a morphine-like opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics.

Oxymorphone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OPANA ER in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

OPANA ER is an extended-release oral formulation of oxymorphone indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.

OPANA ER is NOT intended for use as a prn analgesic.

OPANA ER Tablets are to be swallowed whole and are not to be broken, chewed, dissolved, or crushed. Taking broken, chewed, dissolved, or crushed OPANA ER Tablets leads to rapid release and absorption of a potentially fatal dose of oxymorphone.

Patients must not consume alcoholic beverages, or prescription or non-prescription medications containing alcohol, while on OPANA ER therapy. The co-ingestion of alcohol with OPANA ER may result in increased plasma levels and a potentially fatal overdose of oxymorphone.