The current front-line treatment for early breast cancer, tamoxifen, may have met its match.

Breast cancer survivors are often prescribed medication after their initial therapy. These medicines reduce the level of estrogen, the hormone that drives most breast cancers. It’s not known, though, if women with BRCA gene mutations benefit from these medications.

Medications that block estrogen can be life savers for some breast cancer survivors. But does this approach help all breast cancer survivors?