Vfend

Vfend is a prescription medication used to treat serious fungal infections in the blood and body. Vfend belongs to a group of drugs called azole antifungals which work by slowing the growth of the fungi causing the infection.

This medication comes in tablet and liquid forms to be taken every 12 hours on an empty stomach. Vfend also comes in an injectable form to be given directly into a vein (IV) by a healthcare provider.

Common side effects of Vfend include vision changes, rash, nausea, diarrhea, and headaches.

Vfend is a prescription medicine used to treat certain serious fungal infections in your blood and body. These infections are called:

• Aspergillosis, a fungal infection that begins in the lungs and spreads through the bloodstream to other organs
• Esophageal candidiasis, a yeast-like fungal infection that causes white patching in the mouth and throat
• Scedosporium
• Fusarium
• Candidemia

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

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• Roerig

Vfend may cause serious side effects including:

• liver problems. Symptoms of liver problems may include:
  • itchy skin
  • yellowing of your eyes
  • feeling very tired
  • flu-like symptoms
  • nausea or vomiting
• vision changes. Symptoms of vision changes may include:
  • blurred vision
  • changes in the way you see colors
  • sensitivity to light (photophobia)
• serious heart problems. Vfend may cause changes in your heart rate or rhythm, including your heart stopping (cardiac arrest).
• allergic reactions. Symptoms of an allergic reaction may include:
  • fever
  • sweating
  • feels like your heart is beating fast (tachycardia)
  • chest tightness
  • trouble breathing
  • feel faint
  • nausea
  • itching
  • skin rash
• kidney problems. Vfend may cause new or worse problems with kidney function, including kidney failure. Your healthcare provider should check your kidney function while you are taking Vfend. Your healthcare provider will decide if you can keep taking Vfend.
• serious skin reactions. Symptoms of serious skin reactions may include:
  • rash or hives
  • mouth sores
  • blistering or peeling of your skin
  • trouble swallowing or breathing

Call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the symptoms listed above.

The most common side effects of Vfend include:

• vision changes
• rash
• vomiting
• nausea
• headache
• fast heart beat (tachycardia)
• hallucinations (seeing or hearing things that are not there)
• abnormal liver function tests

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Vfend. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Do not take Vfend if you are taking any of the following medicines:

• cisapride (Propulsid)
• pimozide (Orap)
• quinidine (like Quinaglute)
• sirolimus (Rapamune)
• rifampin (Rifadin)
• carbamazepine (Tegretol)
• long-acting barbiturates like phenobarbital (Luminal)
• ritonavir (Norvir)
• rifabutin (Mycobutin)
• ergotamine, dihydroergotamine (ergot alkaloids)
• St. John's Wort (herbal supplement)

Ask your healthcare provider or pharmacist if you are not sure if you are taking any of the medicines listed above.

Do not start taking a new medicine without talking to your healthcare provider or pharmacist.

Do not take Vfend if you:

• are allergic to Vfend or any of the ingredients in Vfend.
• are taking any of the medicines listed in the section "Drug Interactions".
• You should not drive at night while taking Vfend. Vfend can cause changes in your vision such as blurring or sensitivity to light.
• Do not drive or operate machinery, or do other dangerous activities until you know how Vfend affects you.
• Avoid direct sunlight. Vfend can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get a severe sunburn. Use sunscreen and wear a hat and clothes that cover your skin if you have to be in sunlight. Talk to your healthcare provider if you get sunburn.

Before you take Vfend, tell your healthcare provider if you:

• have or ever had an abnormal heart rate or rhythm. Your healthcare provider may order a test to check your heart (EKG) before starting Vfend.
• have liver or kidney problems. Your healthcare provider may do blood tests to make sure you can take Vfend.
• have trouble digesting dairy products, lactose (milk sugar), or regular table sugar. Vfend tablets contain lactose. Vfend liquid contains sucrose (table sugar).
• are pregnant or plan to become pregnant. Vfend can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Women who can become pregnant should use effective birth control while taking Vfend. 

• are breastfeeding or plan to breastfeed. It is not known if Vfend passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Vfend.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements.

Vfend may affect the way other medicines work, and other medicines may affect how Vfend works.

Know what medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Tell your healthcare provider if you are pregnant or plan to become pregnant. Vfend can harm your unborn baby. Talk to your healthcare provider if you are pregnant or plan to become pregnant. Women who can become pregnant should use effective birth control while taking Vfend.

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if Vfend passes into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Vfend.

• Vfend may be prescribed to you as:
  • intravenous infusion
  • tablets
  • oral suspension
• Vfend intravenous infusion will be given to you by a healthcare provider over 1 to 2 hours.
• Take tablets or oral suspension exactly as your healthcare provider tells you to.
• Take tablets or oral suspension at least 1 hour before or at least 1 hour after meals.
• Vfend oral suspension will be mixed for you by your pharmacist. Do not mix Vfend oral suspension with any other medicine, flavored liquid, or syrup.
• You should not drive at night while taking Vfend. Vfend can cause changes in your vision such as blurring or sensitivity to light.
• Do not drive or operate machinery, or do other dangerous activities until you know how Vfend affects you.
• Avoid direct sunlight. Vfend can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get a severe sunburn. Use sunscreen and wear a hat and clothes that cover your skin if you have to be in sunlight. Talk to your healthcare provider if you get sunburn. 

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your liver function
• type of infection

If you take too much Vfend, call your healthcare provider or go to the nearest hospital emergency room.

• Store Vfend tablets and liquid at room temperature, 59° to 86° F (15° to 30°C). Do not refrigerate or freeze.
• Vfend suspension should be thrown away (discarded) after 14 days.
• Keep Vfend tablets and oral suspension in a tightly closed container.
• Safely throw away medicine that is out of date or no longer needed.
• Keep Vfend, as well as all other medicines, out of the reach of children.