Tobi

Tobi is a prescription medication used to treat lung infections caused by certain bacteria in patients over 6 years old with long-standing cystic fibrosis. Tobi belongs to a group of medicines called aminoglycoside antibiotics. These work to treat infections by inhibiting critical life-sustaining processes within bacteria which causes the bacteria to die.

This medication comes in single-use ampules to be administered through inhalation with the use of a nebulizer machine, typically twice per day.

Common side effects of Tobi include cough, irritation of the nose and/or throat, and lack of energy.

This medication may also cause dizziness. Do not drive or operate heavy machinery until you know how Tobi affects you.

Tobi is a prescription medication used to treat lung infections caused by the bacteria P. aeruginosa in patients over 6 years old with long-standing cystic fibrosis.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your age

The recommended dose of Tobi for the treatment of lung infections caused by the bacteria P. aeruginosa in patients over 6 years old with long-standing cystic fibrosis is 300 mg administered through a nebulizer twice per day for 28 days.

Serious side effects have been reported with Tobi including the following: 

• Hearing loss. Consult with your physician immediately if you experience ringing in your ears while using Tobi, as this can mean your ears are being damaged and may lead to hearing loss.
• Kidney toxicity. Consult with your physician before using Tobi if you have existing kidney disease, as this medication can damage the kidneys.
• Muscle disorders. Consult with your physician before using Tobi if you have any existing neuromuscular disorders, such as myasthenia gravis or Parkinson's disease, as medications like Tobi can aggravate these conditions.
• Difficulty breathing. Discontinue use immediately and seek medical attention if you experience persistent difficulty breathing while using Tobi.

Do not take Tobi if you:

• are allergic to Tobi or to any of its ingredients 

This medication may also cause dizziness. Do not drive or operate heavy machinery until you know how Tobi affects you.

Serious side effects have been reported with Tobi. See the “Tobi Precautions” section.

Common side effects of Tobi include the following:

• cough
• irritation of the nose and/or throat
• lack of energy
• difficulty breathing
• fever
• headache
• lack of appetite
• nausea
• weight loss

This is not a complete list of Tobi side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• abobotulinum toxin A
• acetaminophen
• adefovir
• alendronate
• aluminum hydroxide
• amikacin
• amoxicillin
• amphotericin b
• ampicillin
• aspirin
• atracurium
• avibactam / ceftazidime
• bacitracin
• balsalazide
• benzoic acid
• botulinum toxin type b
• botulism immune globulin
• bromfenac
• bumetanide
• caffeine
• calcium carbonate
• capreomycin
• carboplatin
• cefamandole
• cefazolin
• cefepime
• cefixime
• cefmetazole
• cefonicid
• cefoperazone
• cefotaxime
• cefotetan
• cefoxitin
• ceftaroline
• ceftazidime
• ceftizoxime
• ceftolozane / tazobactam
• ceftriaxone
• cefuroxime
• celecoxib
• cephalothin
• cephapirin
• chlorpheniramine
• cholecalciferol
• choline salicylate
• cidofovir
• cisatracurium
• cisplatin
• clavulanate / ticarcillin
• clofarabine
• cobicistat
• colistimethate
• colistin sulfate
• cyclosporine
• cytomegalovirus immune globulin
• daptomycin
• deferasirox
• desogestrel
• dexamethasone
• dexlansoprazole
• diclofenac
• diflunisal
• diphenhydramine
• doxacurium
• drospirenone
• efavirenz
• emtricitabine
• enflurane
• entecavir
• epinephrine
• esomeprazole
• ethacrynic acid
• ethinyl estradiol
• etidronate
• etodolac
• exenatide
• famotidine
• fenoprofen
• flucytosine
• fluocinolone
• flurbiprofen
• foscarnet
• furosemide
• gallium nitrate
• gentamicin
• gentamicin topical
• hydrocodone
• hyoscyamine
• ibandronate
• ibuprofen
• ifosfamide
• immune globulin
• incobotulinumtoxinA
• indium oxyquinoline in-111
• indomethacin
• insulin inhalation, rapid acting
• kanamycin
• ketoprofen
• ketorolac
• lansoprazole
• lidocaine
• magnesium salicylate
• magnesium sulfate
• mannitol
• meclofenamate
• mefenamic acid
• meloxicam
• mesalamine
• mestranol
• methylprednisolone
• metocurine
• mezlocillin
• mivacurium
• mycophenolate mofetil
• mycophenolic acid
• nabumetone
• naproxen
• neomycin
• netilmicin
• nimodipine
• olsalazine
• omeprazole
• onabotulinumtoxinA
• oxaliplatin
• oxaprozin
• pamidronate
• pancuronium
• pantoprazole
• pemetrexed
• phenylbutazone
• pipecuronium
• piperacillin
• piroxicam
• polymyxin b
• rabeprazole
• rapacuronium
• respiratory syncytial virus immune globulin
• risedronate
• rocuronium
• rofecoxib
• salsalate
• sirolimus
• sodium salicylate
• sodium thiosalicylate
• streptomycin
• succinylcholine
• sulfasalazine
• sulindac
• tacrolimus
• telbivudine
• tenofovir
• ticarcillin
• tiludronate
• tolmetin
• torsemide
• tubocurarine
• typhoid vaccine, live
• valacyclovir
• valdecoxib
• vancomycin
• vecuronium
• zoledronic acid

This is not a complete list of Tobi drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Tobi falls into category D. It has been shown that use of Tobi in pregnant women caused some babies to be born with problems. However, in some serious situations, the benefit of using this medication may be greater than the risk of harm to the baby.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Tobi crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Tobi.