Sylatron

Sylatron is a prescription medication used to prevent malignant melanoma (a kind of skin cancer) from coming back after it has been removed by surgery. Sylatron belongs to a group of drugs called interferons. The way Sylatron treats malignant melanoma is unknown.

Sylatron is a prescription medicine that is used alone to prevent malignant melanoma (a kind of skin cancer) from coming back after it has been removed by surgery. Sylatron should be started within 84 days of surgery to remove lymph nodes containing cancer.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

Malignant Melanoma treatment (Sylatron formulation)

• 6 mcg/kg/week subcutaneously for 8 doses followed by 3 mcg/kg/week subcutaneously for up to 5 years

WARNING: DEPRESSION AND OTHER NEUROPSYCHIATRIC DISORDERS

The risk of serious depression, with suicidal ideation and completed suicides, and other serious neuropsychiatric disorders are increased with alpha interferons, Sylatron Permanently discontinue peginterferon alfa-2b in patients with persistently severe or worsening signs or symptoms of depression, psychosis, or encephalopathy. These disorders may not resolve after stopping Sylatron.

Sylatron can cause serious side effects that:

• may cause death, or
• may worsen certain serious diseases that you may already have.

Tell your healthcare provider right away if you have any of the symptoms listed below while taking Sylatron. If symptoms get worse, or become severe and continue, your healthcare provider may tell you to stop taking Sylatron permanently. In many, but not all people, these symptoms go away after they stop taking Sylatron.

• irritability (getting upset easily)
• depression (feeling low, feeling bad about yourself, or feeling hopeless)
• aggressive behavior
• thoughts of hurting yourself or others, or suicide
• former drug addicts may fall back into drug addiction or overdose

• low blood pressure
• fast heart rate or abnormal heart beat
• trouble breathing or chest pain
• heart attacks or heart muscle problems (cardiomyopathy)

• fever
• chills
• bloody diarrhea
• burning or pain with urination
• urinating often
• coughing up mucus (phlegm) that is discolored (for example, yellow or pink)

Do not take Sylatron with ribavirin if you are pregnant or planning to get pregnant or breastfeeding.

While taking Sylatron, you should see a healthcare provider regularly for check-ups and blood tests to make sure that your treatment is working, and to check for side effects.

Do not take Sylatron:

• if you have had a serious allergic reaction to another alpha interferon or to any of the ingredients in Sylatron. Ask your healthcare provider if you are not sure.
• if you have certain types of hepatitis (autoimmune hepatitis).
• if you have certain other liver problems.
• with ribavirin if you are pregnant, planning to get pregnant, or breastfeeding.

Talk to your healthcare provider before taking Sylatron if you have any of these conditions.

Sylatron may cause serious side effects including:

• See "Drug Precautions".
• Serious eye problems. Sylatron may cause eye problems that may lead to vision loss or blindness. You should have an eye exam before you start taking Sylatron. If you have eye problems or have had them in the past, you may need eye exams while you are taking Sylatron. Tell your healthcare provider or eye doctor right away if you have any vision changes while taking Sylatron.
• Blood problems. Sylatron can affect your bone marrow and cause low white blood cell and platelet counts. In some people, these blood counts may fall to dangerously low levels. If your blood counts become very low, you can get infections, and problems with bleeding and bruising.
• Swelling of your pancreas (pancreatitis) or intestines (colitis).
  Symptoms may include:
  • severe stomach area (abdomen) pain
  • severe back pain
  • nausea and vomiting
  • bloody diarrhea
  • fever
• Lung problems including:
  • trouble breathing
  • pneumonia
  • inflammation of lung tissue
  • new or worse high blood pressure of the lungs (pulmonary hypertension). This can be severe and may lead to death.

• Severe liver problems, or worsening of liver problems, including liver failure and death. Symptoms may include:
  • nausea
  • loss of appetite
  • tiredness
  • diarrhea
  • yellowing of your skin or the white part of your eyes
  • bleeding more easily than normal
  • swelling of your stomach area (abdomen)
  • confusion
  • sleepiness
  • you cannot be awakened (coma)
• Thyroid problems. Some people develop changes in their thyroid function. Symptoms of thyroid changes include:
  • problems concentrating
  • feeling cold or hot all of the time
  • weight changes
  • skin changes
• Blood sugar problems. Some people may develop high blood sugar or diabetes. If you have high blood sugar or diabetes that is not controlled before starting Sylatron, talk to your healthcare provider before you take Sylatron. If you develop high blood sugar or diabetes while taking Sylatron, your healthcare provider may tell you to stop Sylatron and prescribe a different medicine for you. Symptoms of high blood sugar or diabetes may include:
  • increased thirst
  • tiredness
  • urinating more often than normal
  • increased appetite
  • weight loss
  • your breath smells like fruit
• Serious allergic reactions and skin reactions. Symptoms may include:
  • itching
  • swelling of the face, eyes, lips, tongue, or throat
  • trouble breathing
  • anxiousness
  • chest pain
  • feeling faint
  • skin rash, hives, sores in your mouth, or your skin blisters and peels
• Growth problems in children. Weight loss and slowed growth are common in children during treatment with Sylatron.
• Nerve problems. People who take Sylatron or other alpha interferon products with telbivudine (Tyzeka) can develop nerve problems such as continuing numbness, tingling, or burning sensation in the arms or legs (peripheral neuropathy). Call your healthcare provider if you have any of these symptoms.
• Dental and gum problems.

Tell your healthcare provider right away if you have any of the symptoms listed above.

The most common side effects of Sylatron include:

• Flu-like symptoms. Symptoms may include: headache, muscle aches, tiredness, and fever. Some of these symptoms may be decreased by injecting your Sylatron dose at bedtime. Talk to your healthcare provider about which over-the-counter medicines you can take to help prevent or decrease some of these symptoms.
• Tiredness. Many people become very tired during treatment with Sylatron.
• Appetite problems. Nausea, loss of appetite, and weight loss can happen with Sylatron.
• Skin reactions. Redness, swelling, and itching are common at the site of injection.
• Hair thinning.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of Sylatron. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1–800–FDA–1088.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• aldesleukin (Proleukin)
• fluoxetine (Prozac, Sarafem, Symbyax)
• methadone (Dolophine, Methadose)
• pegloticase (Krystexxa)
• ribavirin (Copegus, Rebetol, Ribasphere, Virazole)
• telbivudine (Tyzeka)
• theophylline 
• zidovudine (Retrovir, in Combivir, Trizivir)

This is not a complete list of Sylatron drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Sylatron will harm your unborn baby.

Tell your doctor if you are breastfeeding or plan to breastfeed. You and your healthcare provider should decide if you should use Sylatron or breastfeed. You should not do both.

It is not known if peginterferon alfa-2b will harm your unborn baby. You should use effective birth control during treatment with peginterferon alfa-2b.

Expect to get "flu-like" symptoms when taking peginterferon alfa-2b. To help reduce flu-like symptoms:

• Follow your healthcare provider's instructions about taking acetaminophen before future doses of peginterferon alfa-2b.
• Inject peginterferon alfa-2b at bedtime to help reduce flu-like symptoms.

Your healthcare provider should do regular blood tests before you start peginterferon alfa-2b, and during treatment to see how well the treatment is working and to check you for side effects.