7 Common Questions About Restless Legs Syndrome

Can Medications Worsen Symptoms?

Yes, some cold and allergy medications with antihistamines — such as Benadryl — have been known to worsen symptoms. Other medications that have been linked to worsening RLS symptoms include:

  • Medications for dizziness and nausea such as meclizine, Compazine, Phenergan and Reglan
  • Antidepressants like Elavil, Prozac, Lexapro and Effexor
  • Psychiatric medications like haloperidol and phenothiazines, which are used to treat bipolar disorders, schizophrenia and other serious mental health issues.

Always talk to your doctor before stopping any medications.

Review Date: 
November 20, 2013

Last Updated:
July 1, 2014