Neupogen stimulates the body to produce neutrophils in those receiving strong chemotherapy. The most common side effect is aching in the bones and muscles which can be relieved by Tylenol.

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Neupogen Overview


Neupogen is a prescription medication used to reduce the risk of infection in people with some tumors receiving strong chemotherapy that decreases the number of infection-fighting white blood cells known as neutrophils.

Neupogen belongs to a group of drugs called colony stimulating factors, which stimulate the body to produce neutrophils.

This medication comes in an injectable form that is given just under the skin or directly into a vein (IV), usually once a day.

Common side effects include bone pain and muscle pain.

How was your experience with Neupogen?

First, a little about yourself

Tell us about yourself in a few words?

What tips would you provide a friend before taking Neupogen?

What are you taking Neupogen for?

Choose one
  • Other
  • Neutropenia

How long have you been taking it?

Choose one
  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did Neupogen work for you?

Did you experience many side effects while taking this drug?

How likely would you be to recommend Neupogen to a friend?

Neupogen Cautionary Labels


Uses of Neupogen

Neupogen is a prescription medication used to prevent infections in people getting chemotherapy or bone marrow transplants, or in people who have low neutrophil counts caused by other conditions. It is also used to prepare blood for stem cell collection.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Neupogen Drug Class

Neupogen is part of the drug class:

Side Effects of Neupogen

Serious side effects can occur with Neupogen use. See "Neupogen Precautions".

The most common side effect is aching in the bones and muscles. This aching can usually be relieved by taking a non-aspirin pain reliever such as acetaminophen.

Some people experience redness, swelling, or itching at the site of injection. This may be an allergy to the ingredients in Neupogen, or it may be a local reaction. If you are giving an injection to a child, look for signs of redness, swelling, or itching at the site of injection because they may not be able to tell you they are experiencing a reaction. If you notice any signs of a local reaction, call your doctor.

Neupogen Interactions

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take lithium (Eskalith, Lithobid).

This is not a complete list of Neupogen drug interactions ask your doctor or pharmacist for more information.

Neupogen Precautions

Do not take Neupogen if you are:

  • Allergic to Neupogen or any ingredient in it.
  • Allergic to other medicines made using the bacteria E coli. Ask your doctor if you are not sure.

Neupogen may reduce your chance of getting an infection, but does not prevent all infections. An infection can still happen during the short time when your neutrophil levels are low. You must be alert and look for some of the common signs or symptoms of infection, such as fever, chills, rash, sore throat, diarrhea, or redness, swelling, or pain around a cut or sore. If you have any of these signs or symptoms during treatment with Neupogen, tell your doctor or nurse immediately.

There is a possibility that you could have a reaction at an injection site. If there is a lump, swelling, or bruising at an injection site that does not go away, call your doctor.

If you have a sickle cell disorder, make sure that you tell your doctor before you start taking Neupogen. If you have a sickle cell crisis after getting Neupogen, tell your doctor right away.

Talk to your doctor if you experience unusual bleeding or bruising while taking Neupogen, as this could mean a decrease of platelets which reduces the ability of blood to clot.

If you are receiving Neupogen because you are also receiving chemotherapy, the last dose of Neupogen should be injected at least 24 hours before your next dose of chemotherapy.

The possible serious side effects of Neupogen are:

  • Spleen Rupture. Your spleen may become enlarged and can rupture while taking Neupogen. A ruptured spleen can cause death. The spleen is located in the upper left section of your stomach area. Call your doctor right away if you have pain in the left upper stomach area or left shoulder tip area. This pain could mean your spleen is enlarged or ruptured.
  • Serious Allergic Reactions. Neupogen can cause serious allergic reactions. These reactions can cause a rash over the whole body, shortness of breath, wheezing, dizziness, swelling around the mouth or eyes, fast pulse, and sweating. If you start to have any of these symptoms, stop using Neupogen and call your doctor or seek emergency care right away. If you have an allergic reaction during the injection of Neupogen, stop the injection right away.
  • A serious lung problem called acute respiratory distress syndrome (ARDS). Call your doctor or seek emergency care right away if you have shortness of breath, trouble breathing or a fast rate of breathing.

Neupogen Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Neupogen there are no specific foods that you must exclude from your diet when receiving this medication.


Inform MD

Tell your doctor if you are allergic to Neupogen or any other ingredient in it.

Tell your doctor about all of your medical conditions, especially if you have any diseases of the blood.

Tell your doctor if you are pregnant or breastfeeding.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Neupogen and Pregnancy

Tell  your doctor if you are pregnant or plan to become pregnant. Neupogen has not been studied in pregnant women, and its effects on unborn babies are not known. If you take Neupogen while you are pregnant, it is possible that small amounts of it may get into your baby’s blood.

Neupogen and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Neupogen is excreted in human breast milk or if it will harm your nursing baby.

If you breastfeed during Neupogen treatment, you are encouraged to enroll in Amgen’s Lactation Surveillance Program. You should call 1-800-77-AMGEN (1-800­ 772-6436) to enroll.

Neupogen Usage

Neupogen should be injected at the same time each day. If you miss a dose contact your doctor or nurse.

You must always use the correct dose of Neupogen. Too little Neupogen may not protect you against infections, and too much Neupogen may cause too many neutrophils to be in your blood. Your doctor will determine your/your child’s correct dose based on your body weight.

If you are giving someone else Neupogen injections, it is important that you know how to inject Neupogen, how much to inject, and how often to inject Neupogen.

Neupogen is available as a liquid in vials or in prefilled syringes. When you receive your Neupogen, always check to see that:

  • The expiration date on the vial or prefilled syringe label has not passed. You should not use a vial or prefilled syringe after the date on the label.
  • The strength of the Neupogen (number of micrograms in the colored dot on the package containing the vial or prefilled syringe) is the same as your doctor prescribed.
  • The Neupogen liquid in the vial or in the prefilled syringe is clear and colorless. Do not use Neupogen if the contents of the vial or prefilled syringe appear discolored or cloudy, or if the vial or prefilled syringe appears to contain lumps, flakes, or particles.

If you are using vials of Neupogen only use the syringe that your doctor prescribes.

Your doctor or nurse will give you instructions on how to measure the correct dose of Neupogen. This dose will be measured in milliliters. You should only use a syringe that is marked in tenths of milliliters, or mL (for example, 0.2 mL). The doctor or nurse may refer to an mL as a cc (1 mL = 1 cc). If you do not use the correct syringe, you could receive too much or too little Neupogen.

Only use disposable syringes and needles. Use the syringes only once and dispose of them as instructed by your doctor or nurse.

Neupogen Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

The recommended starting dose of Neupogen is 5 mcg/kg/day‚ given as a single daily injection.

Neupogen Overdose

If you take too much Neupogen, call your local Poison Control Center or seek emergency medical attention right away.

Forms of Medication


    Other Requirements

    • Neupogen should be stored in the refrigerator at 2º to 8ºC (36º to 46ºF), but not in the freezer.
    • Avoid shaking Neupogen.
    • If Neupogen is accidentally frozen, allow it to thaw in the refrigerator before giving the next dose. However, if it is frozen a second time, do not use it and contact your doctor or nurse for further instructions.
    • Neupogen can be left out at room temperature for up to 24 hours.
    • Do not leave Neupogen in direct sunlight.
    • If you have any questions about storage or how to carry Neupogen when you travel, contact your doctor, nurse, or pharmacist.