Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma
Overview[ - collapse ][ - ]
| Purpose | This 2-arm, randomized, phase III study will investigate the efficacy and safety of the addition of rindopepimut (an experimental cancer vaccine that may act to promote anti-cancer effects in patients who have tumors that express the EGFRvIII protein) to the current standard of care (temozolomide) in patients with recently diagnosed glioblastoma, a type of brain cancer. All patients will be administered temozolomide, the standard treatment for glioblastoma. Half the patients will be randomly assigned to receive rindopepimut and half the patients will be randomly assigned to receive a control called keyhole limpet hemocyanin. Patients will be treated in a blinded fashion (neither the patient or the doctor will know which arm of the study the patient is on). Patients will be treated until disease progression or intolerance to therapy and all patients will be followed for survival. |
|---|---|
| Condition | Glioblastoma Small Cell Glioblastoma Giant Cell Glioblastoma Gliosarcoma Glioblastoma With Oligodendroglial Component |
| Intervention | Drug: Rindopepimut (CDX-110) with GM-CSF Drug: Temozolomide Drug: KLH |
| Phase | Phase 3 |
| Sponsor | Celldex Therapeutics |
| Responsible Party | Celldex Therapeutics |
| ClinicalTrials.gov Identifier | NCT01480479 |
| First Received | November 21, 2011 |
| Last Updated | April 16, 2014 |
| Last verified | April 2014 |
Tracking Information[ + expand ][ + ]
| First Received Date | November 21, 2011 |
|---|---|
| Last Updated Date | April 16, 2014 |
| Start Date | November 2011 |
| Estimated Primary Completion Date | Not Provided |
| Current Primary Outcome Measures | Overall Survival [Time Frame: During treatment and every three months from end of treatment through end of study or approximately up to 5 years.] [Designated as safety issue: No]The primary efficacy endpoint of Overall Survival is defined as the number of months from randomization to the date of death (whatever the cause), and will be censored for patients who remain alive at completion of the study for patients with a gross total resection (~n=374). The overall survival of patients will be monitored and compared between the two study arms until the end of the study. |
| Current Secondary Outcome Measures |
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Descriptive Information[ + expand ][ + ]
| Brief Title | Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma |
|---|---|
| Official Title | An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF With Adjuvant Temozolomide in Patients With Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma |
| Brief Summary | This 2-arm, randomized, phase III study will investigate the efficacy and safety of the addition of rindopepimut (an experimental cancer vaccine that may act to promote anti-cancer effects in patients who have tumors that express the EGFRvIII protein) to the current standard of care (temozolomide) in patients with recently diagnosed glioblastoma, a type of brain cancer. All patients will be administered temozolomide, the standard treatment for glioblastoma. Half the patients will be randomly assigned to receive rindopepimut and half the patients will be randomly assigned to receive a control called keyhole limpet hemocyanin. Patients will be treated in a blinded fashion (neither the patient or the doctor will know which arm of the study the patient is on). Patients will be treated until disease progression or intolerance to therapy and all patients will be followed for survival. |
| Detailed Description | The purpose of this research study is to find out whether adding an experimental vaccine called rindopepimut (also known as CDX-110) to the commonly used chemotherapy drug temozolomide can help improve the life expectancy of patients with newly diagnosed, resected EGFRvIII positive glioblastoma. The duration of participation in this study may be up to 5 years. After you are screened and enrolled in the study, you will be administered temozolomide and either rindopepimut/GM-CSF or KLH until either disease progression or intolerance to the medications. If your tumor progresses while on this study, your doctor may treat you with other therapies that are not part of the study. |
| Study Type | Interventional |
| Study Phase | Phase 3 |
| Study Design | Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment |
| Condition |
|
| Intervention | Drug: Rindopepimut (CDX-110) with GM-CSF Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance. Each dose will be 0.8 mL containing approximately 500 mcg CDX-110 and 150 mcg GM CSF. Other Names: CDX-110 with sargramostim (GM-CSF) (Leukine®)Drug: Temozolomide 150 to 200 mg/m2 for 5 days during each 28-day cycle for a minimum of six cycles or a maximum of 12 cycles, or until intolerance or progression. Other Names:
Two intradermal injections two weeks apart, followed by monthly injections until tumor progression or intolerance. Each dose will be 0.8mL containing approximately 100mcg of KLH. |
| Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
| Recruitment Status | Recruiting |
|---|---|
| Estimated Enrollment | 700 |
| Estimated Completion Date | Not Provided |
| Estimated Primary Completion Date | November 2016 |
| Eligibility Criteria | Inclusion Criteria- Among other criteria, patients must meet the following conditions to be eligible for the study: 1. Adult patients, ≥ 18 years old 2. Newly diagnosed glioblastoma 3. Attempted surgical resection followed by conventional chemoradiation 4. Documented EGFRvIII positive tumor status by a Sponsor designated laboratory 5. No evidence of progressive disease from the post-operative period to the post-chemoradiation period 6. Candidate for, and agrees to receive, adjuvant (maintenance) temozolomide therapy 7. Systemic corticosteroid therapy at ≤2 mg of dexamethasone or equivalent per day for at least 3 days prior to randomization 8. WHO-ECOG Performance Status ≤ 2 9. Patients of childbearing/reproductive potential will be instructed to use birth control as defined by your doctor. Exclusion Criteria- Among other criteria, patients who meet the following conditions are NOT eligible for the study: 1. Stereotactic biopsy only (without further surgical resection) 2. Presence of diffuse leptomeningeal disease, gliomatosis cerebri, or infratentorial disease. 3. History, presence, or suspicion of metastatic disease 4. Patients who have received any additional treatment for glioblastoma, aside from surgical resection and chemoradiation with temozolomide 5. Active systemic infection requiring treatment 6. History of any malignancy (other than glioblastoma) during the last three years except non-melanoma skin cancer, in situ cervical cancer, treated superficial bladder cancer, cured, early-stage prostate cancer in a patient with PSA level less than ULN,or other carcinoma in situ that has been adequately treated and cured. 7. Planned major surgery 8. Evidence of current drug or alcohol abuse 9. Known allergy or hypersensitivity to keyhole limpet hemocyanin (KLH), GM-CSF (sargramostim; LEUKINE®), polysorbate 80 or yeast derived products, or a history of anaphylactic reactions to shellfish proteins 10. Severe acute or chronic medical or psychiatric condition or laboratory abnormality that could increase the risk associated with participating in a clinical trial 11. Women who are pregnant or lactating |
| Gender | Both |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Contact: Celldex Therapeutics Info@celldextherapeutics.com |
| Location Countries | United States, Australia, Austria, Belgium, Brazil, Canada, Colombia, Czech Republic, France, Germany, Greece, Hungary, India, Israel, Italy, Mexico, Netherlands, New Zealand, Peru, Spain, Switzerland, Taiwan, Thailand, United Kingdom |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT01480479 |
|---|---|
| Other Study ID Numbers | CDX110-04 |
| Has Data Monitoring Committee | Yes |
| Information Provided By | Celldex Therapeutics |
| Study Sponsor | Celldex Therapeutics |
| Collaborators | Not Provided |
| Investigators | Not Provided |
| Verification Date | April 2014 |
Locations[ + expand ][ + ]
| University of Alabama at Birmingham | Birmingham, Alabama, United States, 35294 Contact: Louis B Nabors, MD | 205-934-1813 | bnabors@uab.eduPrincipal Investigator: Louis B Nabors, MD Recruiting |
|---|---|
| University of South Alabama Mitchell Cancer Institute | Mobile, Alabama, United States, 36604 Contact: Melanie Alford, RN | 251-445-9649 | malford@usouthal.eduPrincipal Investigator: Suzanne Russo, MD Recruiting |
| Barrow Neurological Institute at St. Joseph's Hospital and Medical Center | Phoenix, Arizona, United States, 85013 Contact: Lynn Ashby, MD | 602-406-6262 | LASHBY@CHW.EDUPrincipal Investigator: Lynn Ashby, MD Recruiting |
| University of Arizona Health Network | Tucson, Arizona, United States, 85724 Contact: Jamie Holt | 520-626-6800 | jholt1@email.arizona.eduPrincipal Investigator: Baldassarre Stea, MD, PhD, FASTRO Recruiting |
| University of Arkansas for Medical Sciences | Little Rock, Arkansas, United States, 72205 Contact: Wilma Brooks, RN | 501-686-8530Principal Investigator: Shirley Ong, MD Recruiting |
| Alta Bates Summit Comprehensive Cancer Center | Berkeley, California, United States, 94704 Withdrawn |
| City of Hope Cancer Center | Duarte, California, United States, 91010 Contact: Alexandra Ching | 866-235-3031 | aching@coh.orgPrincipal Investigator: Jana Portnow, MD Recruiting |
| San Diego Pacific Oncology & Hematology Associates, Inc | Encinitas, California, United States, 92024 Withdrawn |
| UC San Diego Moores Cancer Center | La Jolla, California, United States, 92093 Contact: Nadia Faiq | 858-822-1847 | nfaiq@ucsd.eduPrincipal Investigator: Santosh Kesari, MD, PhD Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles, California, United States, 90033 Contact: Aida Lozada, MA | 323-865-3980 | lozada@usc.eduPrincipal Investigator: Rose K Lai, MD Recruiting |
| Chao Family Comprehensive Cancer Center | Orange, California, United States, 92868 Contact: Christina Siwak | 714-456-8549 | csiwak@uci.eduPrincipal Investigator: Daniela Bota Recruiting |
| Kaiser Permanente, Redwood City Medical Center | Redwood City, California, United States, 94063 Contact: Nancy Mendelssohn | 650-299-4165 | nancy.d.mendelssohn@kp.orgPrincipal Investigator: Scott J Peak, MD Recruiting |
| University of California, Davis | Sacramento, California, United States, 95817 Contact: Frances Lara | 916-734-8134 | Frances.lara@ucdmc.ucdavis.eduPrincipal Investigator: Robert O'Donnell, MD, PhD. Recruiting |
| University of California, San Francisco | San Francisco, California, United States, 94143 Contact: Thelma Munoz | 415-353-2523 | munozt@neurosurg.ucsf.eduPrincipal Investigator: Nicholas Butowski Recruiting |
| Stanford Cancer Institute, Stanford University | Stanford, California, United States, 94305 Contact: Sophie Bertrand | 650-723-4467 | sophieb@stanford.eduPrincipal Investigator: Lawrence Recht, MD Recruiting |
| Hartford Hospital | Hartford, Connecticut, United States, 06102 Contact: Danytza Ward, RN | 860-545-5371 | dward02@harthosp.orgPrincipal Investigator: Alexandra Flowers, MD Recruiting |
| Yale University | New Haven, Connecticut, United States, 06520 Contact: Kimberly Hall | 203-737-5228 | Kimberly.hall@yale.eduPrincipal Investigator: Kevin Becker, MD Recruiting |
| Christiana Care Health Services | Newark, Delaware, United States, 19713 Contact: Kathleen Combs, RN, OCN, CCRP | 302-623-4450 | kcombs@christianacare.orgPrincipal Investigator: Michael Guarino, MD Recruiting |
| University of Florida | Gainesville, Florida, United States, 32611 Completed |
| Mount Sinai Medical Center, Comprehensive Cancer Center | Miami Beach, Florida, United States, 33140 Contact: Jose Lutzky,, MD | 305-535-3300 | JLutzky@aptiumoncology.comPrincipal Investigator: Jose Lutzky, MD Recruiting |
| MD Anderson Cancer Center Orlando | Orlando, Florida, United States, 32806 Contact: Mollie Geismer, RN, PhD | 312-841-5206 | mollie.geismer@orlandohealth.comPrincipal Investigator: Nicholas G Avgeropoulous, MD Recruiting |
| Tampa General Hospital | Tampa, Florida, United States, 33606 Contact: Denise Fife,, RN, CCRP | 813-844-7829 | dafife@tgh.orgPrincipal Investigator: Lawrence B Berk, MD, PhD Recruiting |
| Winship Cancer Institute, Emory University School of Medicine | Atlanta, Georgia, United States, 30322 Contact: Costas Hadjipanayis, MD | 404-778-1900 | chadjip@emory.eduPrincipal Investigator: Costas Hadjipanayis, MD Recruiting |
| Atlanta Cancer Care | Atlanta, Georgia, United States, 30005 Contact: Julie F Carney, RN, BSN | 770-777-1315 | jcarney@atlantacancercare.comPrincipal Investigator: Ronald G Steis, MD Recruiting |
| Georgia Health Sciences University | Augusta, Georgia, United States, 30912 Contact: GHSU Referral Office | 888-658-0422 | pbourbo@georgiahealth.eduPrincipal Investigator: Oliver Rixe, MD Recruiting |
| Kaiser Permanente Hawaii Moanalua Medical Center | Honolulu, Hawaii, United States, 96819 Contact: Shelley A Clark,, RN | 808-432-4689 | Shelley.A.Clark@kp.orgPrincipal Investigator: Jennifer F Carney, MD Recruiting |
| University of Chicago | Chicago, Illinois, United States, 60637 Contact: Crista Brawley, PhD | 773-702-0316 | cbrawley@surgery.bsd.uchicago.eduPrincipal Investigator: Maciej Lesniak, MD Recruiting |
| Northwestern University Robert H. Lurie Comprehensive Cancer Center | Chicago, Illinois, United States, 60611 Contact: Jeffrey Raizer, MD | 312-695-1301 | cancertrials@northwestern.eduPrincipal Investigator: Jeffrey Raizer, MD Recruiting |
| Rush University Medical Center | Chicago, Illinois, United States, 60612 Contact: Amanda Begley, RN, BS | 312-563-2713 | Amanda_Begley@rush.eduPrincipal Investigator: Nina Paleologos, MD Recruiting |
| North Shore University Health System | Evanston, Illinois, United States, 60201 Contact: Patricia Lada, RN | 847-570-2025 | plada@northshore.orgPrincipal Investigator: Ryan Merrell, MD Recruiting |
| Loyola University Medical Center | Maywood, Illinois, United States, 60153 Contact: Sandra Zakrweski, BSN | 708-327-2831 | SZakrze@lumc.eduPrincipal Investigator: Kevin Barton, MD Recruiting |
| Covenant Clinic / Iowa Spine and Brain Institute | Waterloo, Iowa, United States, 50702 Contact: Kimberly Maxfield, RN | 319-272-2388 | kimberly.maxfield@wfhc.orgPrincipal Investigator: Timothy Ryken, MD Recruiting |
| University of Kentucky | Lexington, Kentucky, United States, 40536-0093 Contact: John L Villano, MD, PhD | 859-323-8043 | jlvillano@uky.eduPrincipal Investigator: John L Villano, MD, PhD Recruiting |
| Norton Cancer Institute | Louisville, Kentucky, United States, 40202 Contact: Leanne Coleman, RN | 502-629-4594 | leanne.coleman@nortonhealthcare.orgPrincipal Investigator: Renato LaRocca, MD Recruiting |
| Mary Bird Perkins Cancer Center | Baton Rouge, Louisiana, United States, 70809 Contact: Karla Tullier, RN, BSN | 225-215-1129 | ktullier@marybird.comPrincipal Investigator: Jon Olson, MD Recruiting |
| LSU Health Sciences Center, Feist-Weiller Cancer Center | Shreveport, Louisiana, United States, 71103 Contact: Stacy Moss | 318-813-1422 | smoss@lsuhsc.eduPrincipal Investigator: Gary V Burton, MD Recruiting |
| Anne Arundel Medical Center | Annapolis, Maryland, United States, 21401 Contact: Emily Ross, CCRC | 443-481-4392 | eross@aahs.orgPrincipal Investigator: Peter Graze, MD Recruiting |
| Johns Hopkins University School of Medicine | Baltimore, Maryland, United States, 21231 Contact: Susan Zhen, RN | 410-502-4081 | szhen1@jhmi.eduPrincipal Investigator: Michael Lim, MD Recruiting |
| Center for Cancer and Blood Disorders, PC | Bethesda, Maryland, United States, 20817 Contact: Natalie Bongiorno, RN,BSN,MSHS | 301-571-2016 | nbongiorno@ccbdmd.comPrincipal Investigator: Ralph Boccia, MD Recruiting |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States, 02215 Contact: Debra LaFrankie, RN | 617-632-6327 | debra_lafrankie@dfci.harvard.eduPrincipal Investigator: Lakshmi Nayak, MD Recruiting |
| University of Massachusetts Memorial Medical Center | Worcester, Massachusetts, United States, 01655 Contact: Kathryn Clarke | 508-856-5461 | kathryn.clarke@umassmemorial.orgPrincipal Investigator: Shakeeb Yunus, MD Recruiting |
| University of Michigan Health System | Ann Arbor, Michigan, United States, 48109 Contact: Larry Junck, MD | 734-936-7910 | ljunck@umich.eduPrincipal Investigator: Larry Junck, MD Recruiting |
| Edward W. Sparrow Hospital Association - Sparrow Regional Cancer Center | Lansing, Michigan, United States, 48912 Contact: Harsha Trivedi, PhD | 517-364-3712 | harsha.trivedi@sparrow.orgPrincipal Investigator: Gordan Srkalovic, MD, PhD. Recruiting |
| St. Mary's of Michigan Medical Center/Field Neurosciences Institute | Saginaw, Michigan, United States, 48604 Contact: Richard Herm, MSN, RN | 989-497-3046 | rherm@stmarysofmichigan.orgPrincipal Investigator: Malcolm Field, MD Recruiting |
| Allina Health, Abbott Northwestern Hospital, John Nasseff Neuroscience Institute | Minneapolis, Minnesota, United States, 55407 Contact: Grace Wilson, RN, BSN | 612-863-9166 | grace.wilson@allina.comPrincipal Investigator: John E Trusheim, MD Recruiting |
| Ellis Fischel Cancer Center | Columbia, Missouri, United States, 65203 Contact: Chris Ehlenbeck, RN | 573-882-7440 | ehlenbeckc@health.missouri.eduPrincipal Investigator: Carl Freter, MD Recruiting |
| Washington University in St. Louis | St. Louis, Missouri, United States, 63110 Contact: Madelyn Kissel | 314-747-5384 | mkissel@dom.wustl.eduPrincipal Investigator: David Tran, MD Recruiting |
| Southeast Nebraska Cancer Center | Lincoln, Nebraska, United States, 68510 Contact: Lindsay Clements, RN,BSN,OCN | 402-327-7363 | lindsayc@leadingcancercare.comPrincipal Investigator: Stacey Knox, MD Recruiting |
| Dartmouth Hitchcock Medical Center | Lebanon, New Hampshire, United States, 03756 Contact: Crystalle J Newton | 603-650-4428 | Crystalle.J.Newton@hitchcock.orgPrincipal Investigator: Camilo Fadul, MD, F.A.A.N Recruiting |
| New Jersey Neuroscience Institute, JFK Medical Center | Edison, New Jersey, United States, 08818 Contact: Charles Porbeni, MD, BS, MSC | 732-321-700068897 | CPorbeni@JFKHealth.orgPrincipal Investigator: Joseph Landolfi, DO Recruiting |
| John Theurer Cancer Center at Hackensack University Medical Center | Hackensack, New Jersey, United States, 07601 Contact: Lori Cappello, RN | 201-996-5098 | LCappello@humed.comPrincipal Investigator: Samuel A Goldlust, MD Recruiting |
| Monmouth Medical Center | Long Branch, New Jersey, United States, 07740 Contact: Heather Paxton, R.N. | 732-923-6557 | hpaxton@barnabashealth.orgPrincipal Investigator: Sumul N Raval, MD Recruiting |
| Dent Neurosciences Research Institute | Amherst, New York, United States, 14226 Contact: Olga I Ananina, BS, CRC | 716-558-5670 | oananina@dentinstitute.comPrincipal Investigator: Laszlo L Mechtler, MD Recruiting |
| Montefiore Medical Center | Bronx, New York, United States, 10467 Contact: Hilda Haynes-Lewis, NP | 718-920-8819 | hhayes@montefiore.orgPrincipal Investigator: Jerome Graber, MD Recruiting |
| New York Methodist Hospital | Brooklyn, New York, United States, 11215 Contact: Adel Guirquis, MD, MS | 718-780-3677 | adg9003@nyp.orgPrincipal Investigator: Hani Ashamalla, MD, FCCP Recruiting |
| The Long Island Brain Tumor Center at Neurology Surgery, P.C. | Great Neck, New York, United States, 11021 Contact: Kimberly Prabhu, MA, CCRP | 516-478-0010 | kprabhu@nspc.comPrincipal Investigator: J. Paul Duic, M.D. Recruiting |
| North Shore University Hospital | Manhasset, New York, United States, 11030-3186 Contact: Michael Schulder, MD | 516-562-3065 | mschulder@nshs.eduPrincipal Investigator: Michael Schulder, MD Recruiting |
| Columbia University Medical Center - The Neurologic Institute of New York | New York, New York, United States, 10032 Contact: Fabio Iwamoto, M.D. | 212-342-0571 | fi2146@columbia.eduPrincipal Investigator: Fabio Iwamato, MD Recruiting |
| Weill Cornell Medical College | New York, New York, United States, 10065 Contact: Melissa D. Ricketts | 212-746-7373 | mdr2001@med.cornell.eduPrincipal Investigator: Susan Pannullo, MD Recruiting |
| University of Rochester Medical Center | Rochester, New York, United States, 14642 Contact: Jennifer Serventi, RPA-C | 585-276-3971 | jennifer_servent@urmc.rochester.eduPrincipal Investigator: Nimish A Mohile, MD Recruiting |
| SUNY Upstate Medical University | Syracuse, New York, United States, 13210 Contact: Wendy Barry | 315-464-8271 | barryw@upstate.eduPrincipal Investigator: Thomas E Coyle, MD Recruiting |
| Brain and Spine Surgeons of New York | White Plains, New York, United States, 10604 Contact: Jan Strack, RN | 914-517-7982 | jstrack@bssny.comPrincipal Investigator: John Abrahams, MD Recruiting |
| The Preston Robert Tisch Brain Tumor Center at Duke University Medical Center | Durham, North Carolina, United States, 27710 Contact: Alise Brickhouse, CRC | 919-684-3107 | alise.brickhouse@duke.eduPrincipal Investigator: Annick Desjardins, MD Recruiting |
| Wake Forest Baptist Health | Winston-Salem, North Carolina, United States, 27157 Contact: Jennifer Maclean, BS, RN | 336-713-3539 | jemaclea@wakehealth.eduPrincipal Investigator: Glenn Lesser, MD Recruiting |
| University of Cincinnati Cancer Institute | Cincinnati, Ohio, United States, 45267 Contact: Suzanne Sifri, BSN | 513-584-0618 | Suzanne.sifri@uc.eduPrincipal Investigator: Rekha Chaudhary, MD Recruiting |
| Cleveland Clinic Foundation | Cleveland, Ohio, United States, 44195 Contact: Gene Barnett, MD | 216-444-5381Principal Investigator: Gene Barnett, MD Recruiting |
| University Hospitals, Case Medical Center (Cleveland) | Cleveland, Ohio, United States, 44106 Contact: Henry Krzemien | 216-983-3021 | Henry.krzemien@uhhospitals.orgPrincipal Investigator: Andrew Sloan, MD Recruiting |
| Ohio State University | Columbus, Ohio, United States, 43210 Contact: Jill Brown, MS | 614-293-5554 | jill.brown@osumc.eduPrincipal Investigator: Herbert Newton, MD Recruiting |
| Providence Portland Medical Center, Oncology & Hematology Care | Portland, Oregon, United States, 97213 Contact: Chris Fountain, RN | 503-215-2691 | Christopher.fountain@providence.orgPrincipal Investigator: Marka Crittenden, MD Recruiting |
| Pacific Neurosurgical | Portland, Oregon, United States, 97227 Contact: Susan Staat, RN | 503-413-8330 | sstaat@lhs.orgPrincipal Investigator: Jeff Chen, MD Recruiting |
| Lehigh Valley Physician Group-Hematology-Oncology Associates | Allentown, Pennsylvania, United States, 18103 Contact: Yasmin O Candelo, RN | 610-402-9543 | Yasmin_O.Candelo@lvhn.orgPrincipal Investigator: Suresh Nair, MD Recruiting |
| Temple University Hospital | Philadelphia, Pennsylvania, United States, 19140 Contact: Douglas W Laske, MD | 215-707-2618 | dlaske@temple.eduPrincipal Investigator: Douglas Laske, MD Recruiting |
| University of Pennsylvania | Philadelphia, Pennsylvania, United States, 19104 Contact: Francis Quattrone, BS, CRC | 215-615-4590 | Francis.Quattrone@uphs.upenn.eduPrincipal Investigator: James Schuster, MD, PhD Recruiting |
| West Penn. Allegheny Health System | Pittsburg, Pennsylvania, United States, 15212 Contact: Gloria Flannery, RN | 412-359-8379 | gflanner@wpahs.orgPrincipal Investigator: Jane Raymond, MD Recruiting |
| University of Pittsburgh Cancer Institute | Pittsburgh, Pennsylvania, United States, 15232 Contact: Rita Johnson | 412-647-8571 | johnsonr1@upmc.eduPrincipal Investigator: Jan Drappatz, MD Recruiting |
| Medical University of South Carolina - Department of Neuroscience | Charleston, South Carolina, United States, 29425 Contact: Michele DeCandio, RN, OCN, CCRP | 843-792-9016 | decandio@musc.eduPrincipal Investigator: Bruce Frankel, MD Recruiting |
| University of Tennessee Medical Center - Knoxville | Knoxville, Tennessee, United States, 37920 Contact: Shanna Overbey, RN | 865-305-97734 | soverbey@utmck.eduPrincipal Investigator: Wahid Hanna, MD Recruiting |
| Sarah Cannon Research Institute | Nashville, Tennessee, United States, 37203 Contact: Kent Shih, MD | 615-329-7274 | kshih@tnonc.comPrincipal Investigator: Kent Shih, MD Recruiting |
| Vanderbilt-Ingram Cancer Center | Nashville, Tennessee, United States, 37232 Contact: VICC-Clinical Trials Information Program | 800-811-8480 | viccweb@vanderbilt.eduPrincipal Investigator: Reid Thompson, MD Recruiting |
| Texas Oncology Midtwon | Austin, Texas, United States, 78705 Contact: Marlena Griffin,, BSc | 512-421-4100 | marlena.griffin@usoncology.comPrincipal Investigator: Morris D Groves, MD Recruiting |
| Baylor Research Institute | Dallas, Texas, United States, 75246 Contact: Clinical Oncology Research Coordination | 214-818-8472 | cancer.trials@baylorhealth.eduPrincipal Investigator: Karen Fink, MD, PhD Recruiting |
| The Methodist Neurological Institute | Houston, Texas, United States, 77030 Contact: Kimbra S Harris, CCRP | 713-441-3800 | ksharris@tmhs.orgPrincipal Investigator: Pamela Z New, MD Recruiting |
| University of Utah Department of Neurosurgery | Salt Lake City, Utah, United States, 84112 Contact: Katy Philips | 801-587-4420Principal Investigator: Randy Jensen, MD Recruiting |
| Fletcher Allen Health Care | Burlington, Vermont, United States, 05405 Contact: Kate Murray, BS | 802-656-9401 | Kathryn.Murray@uvm.eduPrincipal Investigator: Steven Emmons, MD Recruiting |
| University of Virginia Healthcare System | Charlottesville, Virginia, United States, 22908 Contact: Kim Chapman | 434-243-9360 | kc9zy@virginia.eduPrincipal Investigator: Benjamin Purow, MD Recruiting |
| Swedish Neuroscience Institute | Seattle, Washington, United States, 98122 Contact: Nathan Hansen, BA | 206-320-3542 | nathan.hansen@swedish.orgPrincipal Investigator: John W Henson, MD FAAN Recruiting |
| University of Washington Medical Center | Seattle, Washington, United States, 98195 Contact: Fereshteh Assadian, RN | 206-288-6693 | fassadia@uw.eduPrincipal Investigator: Maciej Mrugala, MD Recruiting |
| University of Wisconsin Paul P Carbone Comprehensive Cancer Center | Madison, Wisconsin, United States, 53792 Contact: Ian Robins, MD PhD | 608-263-1416 | hirobins@wisc.eduPrincipal Investigator: Ian H Robins, MD Recruiting |
| Medical College of Wisconsin | Milwaukee, Wisconsin, United States, 53226 Contact: Jennifer Connelly, MD | 414-805-5204 | jconnelly@mcw.eduPrincipal Investigator: Jennifer Connelly, MD Recruiting |
| Prince of Wales Hospital | Randwick, New South Wales, Australia, 2031 Contact: Elizabeth Hovey, MSc, MBBS, FRACP | 61 2 9382 2956Principal Investigator: Elizabeth Hovey, MSc, MBBS, FRACP Recruiting |
| Royal North Shore Hospital | St Leonards, New South Wales, Australia, 2605 Contact: Helen R Wheeler, MBBS FRACP | 61 2 94371900 | hrwheeler@optusnet.com.auPrincipal Investigator: Helen R Wheeler, MBBS FRACP Recruiting |
| The Crown Princess Mary Cancer Centre, Westmead Hospital | Westmead, New South Wales, Australia, 2145 Contact: Ka Yeung Mark Wong, MBBS FRACP PhD | 61 2 9845 5200 | mark.wong@sydney.edu.auPrincipal Investigator: Ka Yeung Mark Wong, MBBS FRACP PhD Recruiting |
| Royal Brisbane and Women's Hospital | Herston, Queensland, Australia, 4029 Contact: Po-Ling Inglis, BSc, MBBS, FRACP | 61 7 3636 7712Principal Investigator: Po-Ling Inglis, BSc, MBBS, FRACP Recruiting |
| Mater Adult Hospital, Mater Misericordiae Health Services Brisbane Limited | South Brisbane, Queensland, Australia, 4101 Completed |
| Royal Adelaide Hospital | Adelaide, South Australia, Australia, 5000 Contact: Nimit Singhal, MBBS FRACP | 61-8-822-4398 | nimit.singhal@health.sa.gov.auPrincipal Investigator: Nimit Singhal, MBBS FRACP Recruiting |
| Calvary North Adelaide Hospital | North Adelaide, South Australia, Australia, 5006 Contact: William K Patterson, MBBS FRACP | 61 8 8463 2500 | William.Patterson@health.sa.gov.auPrincipal Investigator: William K Patterson, MBBS FRACP Recruiting |
| Royal Hobart Hospital | Hobart, Tasmania, Australia, 7000 Contact: Rosemary A Harrup, MBBS | 61-3-6222-8157 | rosemary.harrup@dhhs.tas.gov.auPrincipal Investigator: Rosemary A Harrup, MBBS Recruiting |
| Launceston General Hospital | Launceston, Tasmania, Australia, 7250 Contact: Stainslaw Gauden, MBBS, FRACP | 61 3 6348 7140Principal Investigator: Stainslaw Gauden, MBBS, FRACP Recruiting |
| Monash Medical Centre | Clayton, Victoria, Australia, 3199 Contact: Jason Derrick Lickliter, MBBS FRACP | 61 3 9594 7100 | jason.lickliter@monash.eduPrincipal Investigator: Jason Derrick Lickliter, MBBS FRACP Recruiting |
| Austin Health | Heidelberg, Victoria, Australia, 3084 Contact: Lawrence M Cher, MBBS | 61 3 9625-2323 | lmcher@mac.comPrincipal Investigator: Lawrence M Cher, MBBS Recruiting |
| Epworth Healthcare | Richmond, Victoria, Australia, 3121 Contact: Ross R Jennens, MBBS | 61-3-9421-6085 | jennens@bigpond.net.auPrincipal Investigator: Ross R Jennens, MBBS Recruiting |
| Sir Charles Gairdner Hospital | Nedlands, Western Australia, Australia, 06008 Contact: Anna Nowak, MBBS FRACP PhD | 61 8 9346 3841 | anowak@meddent.uwa.edu.auPrincipal Investigator: Anna Nowak, MBBS FRACP PhD Recruiting |
| Liverpool Hospital | Liverpool, Australia, 2107 Contact: Paul Linus de Souza, MBBS FRACP | 61 2 9616 4407 | p.desousa@uws.edu.auPrincipal Investigator: Paul Linus de Souza, MBBS FRACP Recruiting |
| Medical University Innsbruck, Dept of Neurology, Anichstrabe 35 | Innsbruck, Austria, 6020 Contact: Günther Stockhammer, Ao.Univ.-Prof.Dr. | 43 512 504 26310 | guenther.stockhammer@i-med.ac.atPrincipal Investigator: Günther Stockhammer, Ao.Univ.-Prof.Dr. Recruiting |
| Medizinische Universität Wien, Innere Medizin I, Onkologie | Vienna, Austria, 1090 Contact: Christine Marosi, a.o. Univ. Prof. Dr. | 431404004421 | christine.marosi@meduniwien.ac.atPrincipal Investigator: Christine Marosi, a.o.Univ.Prof.Dr Recruiting |
| Universitair Ziekenhuis Antwerpen | Edegem, Antwerp, Belgium, 2650 Contact: Iris Verhaegen | 32 (0) 3 821 5681 | iris.verhaegen@uza.bePrincipal Investigator: Pol Specenier, MD, PhD Recruiting |
| ZNA Middelheim | Antwerpen, Belgium, B-2020 Contact: Frank Van Fraeyenhove, Dr | +32 3 280 40 40 | ffraeyenhove@yahoo.comPrincipal Investigator: Frank Van Fraeyenhove, Dr Recruiting |
| Ghent University Hospital | Ghent, Belgium, 9000 Contact: Tom Boterberg, MD | +3293323015 | tom.boterberg@ugent.bePrincipal Investigator: Tom Boterberg, MD Recruiting |
| NEO-Núcleo de Estudos Oncológico | Curitiba, Paraná, Brazil, 80440-210 Withdrawn |
| Hospital Mae de Deus-Centro de Pesquisa em Oncologia Clinica | Porto Alegre, Rio Grande do Sul, Brazil, 90840-440 Contact: Fabiana Spillari Viola, MD | 55 51 32523930 | fsviola@terra.com.brPrincipal Investigator: Fabiana Spillari Viola, MD Recruiting |
| Centro de Pesquisas Clinicas da Fundação Dr Amaral Carvalho | Jaú, São Paulo, Brazil, 17210-120 Contact: Gustavo Fernando Veraldi Ismael, MD | 55 14 3602-1399 | gismael@uol.com.brPrincipal Investigator: Gustavo Fernando Veraldi Ismael, MD Not yet recruiting |
| Fundação Faculdade Regional de Medicina de de São José do Rio Preto - Hospital de Base | São José do Rio Preto, São Paulo, Brazil, 15090-000 Contact: Gustavo Colagiovanni Girotto, MD | 55-17-81194244 | oncofamerp@yahoo.com.brPrincipal Investigator: Gustavo Colagiovanni Girotto, MD Recruiting |
| Instituto Nacional do Cancer (INCA) | Rio de Janeiro, Brazil, 20231-050 Contact: Clarissa Serôdio da Rocha Baldotto, MD | 55 21 3207 6585 | cbaldotto@gmail.comPrincipal Investigator: Clarissa Serôdio da Rocha Baldotto, MD Recruiting |
| Hospital Albert Einstein | Sao Paulo, Brazil, 05652-900 Contact: Suzana Maria F Malheiros, MD | 55 11 2151-1127 | smfmalheiros@gmail.comPrincipal Investigator: Suzana Maria F Malheiros, MD Recruiting |
| Hospital A C Camargo | São Paulo, Brazil, 01509-900 Contact: Ana Carolina Sigolo Levy, MD | 55 11 21895178 | ana.levy@accamargo.org.brPrincipal Investigator: Ana Carolina Sigolo Levy, MD Recruiting |
| Instituto do Câncer do Estado de São Paulo - ICESP | São Paulo, Brazil, 01246-000 Contact: Olavo Feher, MD | 55-11-38932619 | ofeher@terra.com.brPrincipal Investigator: Olavo Feher, MD Recruiting |
| Real e Benemerita Associação Portuguesa de Beneficiência/ Hospital São José | São Paulo, Brazil, 01321-001 Contact: Marcos André de Sá Barreto Costa, MD | 55 11 3505 6693 | mandre_med@yahoo.com.brPrincipal Investigator: Marcos André de Sá Barreto Costa, MD Recruiting |
| Foothills Hospital Medical Centre | Calgary, Alberta, Canada, T3J 5N6 Contact: Ish Bains | 403-944-4334 | ish.bains@albertahealthservices.caPrincipal Investigator: Mark Hamilton, MD Recruiting |
| British Columbia Cancer Agency, Vancouver Clinic | Vancouver, British Columbia, Canada, V5Z 4E6 Contact: Shane Brown | 604-877-60002370 | sbrown9@bccancer.bc.caPrincipal Investigator: Brian Thiessen, MD Recruiting |
| BC Cancer Agency - Vancouver Island Centre | Victoria, British Columbia, Canada, V8X 4V6 Contact: John P McGhie, MD | 250-519-5580 | jmcghie@bccancer.bc.caPrincipal Investigator: John P McGhie, MD Recruiting |
| University of Manitoba-Cancer Care Manitoba | Winnipeg, Manitoba, Canada, R3E0V9 Contact: Marshall Pitz, MD, FRCPC | 204-787-2108 | pitz@cc.umanitoba.caPrincipal Investigator: Marshall Pitz, MD, FRCPC Recruiting |
| QEII Health Sciences Centre | Halifax, Nova Scotia, Canada, B3H 1V7 Contact: Sharon Hebb | 902-473-2161 | sharon.hebb@cdha.nshealth.caPrincipal Investigator: Mary MacNeil, MD Recruiting |
| Juravinski Cancer Centre | Hamilton, Ontario, Canada, L8V 5C2 Contact: Lisa Rudd-Scott, RN, BScN MN | 905-387-971164407 | lisa.rudd-scott@jcc.hhsc.caPrincipal Investigator: Hal Hirte, MD Recruiting |
| London Regional Cancer Program, London Health Sciences Centre | London, Ontario, Canada, N6A 4L6 Contact: David R Macdonald, MD | David.Macdonald@lhsc.on.caPrincipal Investigator: David Macdonald, MD Recruiting |
| Ottawa Hospital, Regional Cancer Centre | Ottawa, Ontario, Canada, K1H 8L6 Contact: Roxanne Ward | 613-737-770073328 | rward@ohri.caPrincipal Investigator: Garth Nicholas, MD Recruiting |
| Sunnybrook Health Sciences Centre | Toronto, Ontario, Canada, M4N3M5 Contact: Hyla Okorofsky, RN | 416-480-50007474 | hyla.okorofsky@sunnybrook.caPrincipal Investigator: James Perry, MD Recruiting |
| Montreal Neurological Institute and Hospital | Montreal, Quebec, Canada, H3A 2B4 Contact: Marc Lemieux | 514-398-2667 | marc.lemieux@mcgill.caPrincipal Investigator: Petr Kavan, MD Recruiting |
| Centre Hospitalier de l'Universite de Montreal (CHUM) - Hopital Notre-Dame | Montreal, Quebec, Canada, H2L 4M1 Contact: Karl Belanger, MD | 514-890-800025381 | karl.belanger.chum@ssss.gouv.qc.caPrincipal Investigator: Karl Belanger, MD Recruiting |
| CHUQ - L'Hôtel-Dieu De Québec | Québec, Quebec, Canada, G1R2J6 Contact: Josée Allard, RN | 418-691-5264Principal Investigator: Isabelle Valliéres, MD Recruiting |
| CHUS Hôpital Fleurimont | Shenbrooke, Quebec, Canada, J1H5N4 Contact: David Mathieu, MD | 819-346-111014887Principal Investigator: David Mathieu, MD Recruiting |
| CHUQ L'Hotel Dieu | Quebec, Canada, G1R 2J6 Contact: Josee Allard | 418-525-444416730 | josee.allard@chug.qc.caPrincipal Investigator: Nathalie Lessard, MD Recruiting |
| Fundacion Santa Fe | Bogota, Bogota D.C, Colombia, 000 Contact: Martha L Celis Herrans | +57-3123722226 | martha.celis@fsfb.org.coPrincipal Investigator: Andres Felipe Cardona, MD Recruiting |
| Clinica del Country | Bogota D.C., Colombia Withdrawn |
| Hospital Ceske Budejovice | Ceske Budejovice, Czech Republic, 370 01 Contact: Petr Vitek, MD | 00420 387 875 001 | vitek@nemcb.czPrincipal Investigator: Petr Vitek, MD Recruiting |
| Hospital Na Homolce | Prague, Czech Republic, 150 30 Contact: Jan Sroubek, MD | 00420 257 273 091 | jan.sroubek@homolka.czPrincipal Investigator: Jan Sroubek, MD Recruiting |
| Fakultni nemocnice Motol | Praha, Czech Republic, 150 06 Contact: Bela Malinova, MD | 00420 224 434 764 | Bela.Malinova@fnmotol.czPrincipal Investigator: Bela Malinova, MD Recruiting |
| Multiscan s.r.o. | Praha 5, Czech Republic, 155-00 Contact: Karel Odrazka, MD, PhD | 00420 466 016 413 | odrazka@seznam.czPrincipal Investigator: Karel Odrazka, MD, PhD Recruiting |
| Masaryk´s Hospital Usti nad Labem | Usti nad Labem, Czech Republic, 401-13 Contact: Martin Sames, MD, PhD | 00420 477 112 871 | Martin.Sames@KZCR.EUPrincipal Investigator: Martin Sames, MD, PhD Recruiting |
| Institut de Cancerologie de I'Quest-Paul Papin | Angers, France, 49933 Contact: Patrick Soulie, MD | +33 2 41 35 27 00 | Patrick.Soulie@ico.unicancer.frPrincipal Investigator: Patrick Soulie, MD Recruiting |
| Institute Bergonie | Bordeaux, France, 33076 Contact: Guy Kantor, MD | 33 556333333 | g.kantor@bordeaux.unicancer.frPrincipal Investigator: Guy Kantor, MD Not yet recruiting |
| Institut de Cancerologie de L'Quest-Center Rane Gauducheau | Nantes, France, 44805 Contact: Mario Campone, MD | +33 2 40 679 977 | mario.campone@ico.unicancer.frPrincipal Investigator: Mario Campone, MD Recruiting |
| Service de Neurologie-GH | Paris, France, 75013 Contact: Ahmed Idbaih, MD | 00 33 1 42 16 04 31 | ahmed.idgaih@gmail.comPrincipal Investigator: Ahmed Idbaih, MD Recruiting |
| Centre Eugene Marquis | Rennes, France, 35042 Contact: Elodie Vauleon, MD | 00 33 2 99 25 32 26 | e.vauleon@rennes.unicancer.frPrincipal Investigator: Elodie Vauleon, MD Recruiting |
| Institut Gustave Roussy | Villejuif, France, 94805 Contact: Julien Domont, MD | 00 33 1 42 11 43 16 | julien.domont@igr.frPrincipal Investigator: Julien Domont, MD Recruiting |
| Klinik und Poliklinik fur Neurologie der Universitat Regensburg | Regensburg, Bavaria, Germany, 93053 Contact: Peter Hau, Prof. Dr. | ++49(0)9419418464 | Peter.Hau@medbo.dePrincipal Investigator: Peter Hau, Prof. Dr. Not yet recruiting |
| Strahlenklinik Universitatsklinikum Erlangen | Erlangen, Germany, D-91054 Contact: Dorota Lubgan, PhD. | +49-(0)9131-85-44254 | Dorota.Lubgan@uk-erlangen.dePrincipal Investigator: Rainer Fietkau, Prof. Dr. med. Not yet recruiting |
| Universitaetsklinikum Heidelberg, Neurologische Klinik, IM Neuenheimer Feld 672 | Heidelberg, Germany, 69120 Contact: Wolfgang Wick, Prof. MD | +0049 6221 56 7075 | wolfgang.wick@med.uni-heidelberg.dePrincipal Investigator: Wolfgang Wick, Prof. Dr. Not yet recruiting |
| University Medical Centre | Kiel, Germany, 24105 Contact: Brigitte Hirschhausen | +49 431 597 88074907 | brigitte.hirschhausen@UKSH.dePrincipal Investigator: Maximilian Mehdorn, MD Recruiting |
| Universitaetsklinikum Muenster | Muenster, Germany, 48149 Contact: Oliver Grauer, MD PhD | 0049 251 83 46814 | oliver.grauer@ukmuenster.dePrincipal Investigator: Oliver Grauer, MD PhD Recruiting |
| LMU Munich | Munich, Germany, D-81377 Contact: Oliver Schnell, Dr | +49 (0)89 7095-0 | oschnell@med.lmu.dePrincipal Investigator: Oliver Schnell, Dr Not yet recruiting |
| NNA | Athens, Attiki, Greece, 11521 Contact: Panagiotis Papadopoulos, MD, PhD | +302107261374 | pgpapad@gmail.comPrincipal Investigator: Panagiotis Papadopoulos, MD, PhD Recruiting |
| "HYGEIA" Hospital | Marousi, District of Attica, Greece, 151 23 Contact: Evangelia Razi, MD, PhD | 30 210 6867165 | e.razis@hygeia.grPrincipal Investigator: Evangelia Razi, MD, PhD Recruiting |
| Országos Onkológiai Intézet Sugárterápiás Osztály | Budapest, Hungary, 1122 Contact: József Lövey, MD, Prof | +36 20 455 3579 | lovey@oncol.huPrincipal Investigator: József Lövey, MD. Prof Recruiting |
| Debreceni Egyetem Orvos- és Egészségtudományi Centrum Onkológiai Intézet | Debrecen, Hungary, 4032 Contact: Zsolt Horvath, Prof. Dr | 3606304913443 | horvathzsolt@med.unideb.huPrincipal Investigator: Zsolt Horvath, Dr Recruiting |
| Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház, Sugárterápiás Osztály | Miskolc, Hungary, 3526 Contact: Katalin Molnár, Dr | 36 30 203 2489 | moka.onkorad@bazmkorhaz.huPrincipal Investigator: Katalin Molnár, MD Recruiting |
| Pécsi Tudományegyetem Általános Orvostudományi Kar | Pécs, Hungary, 7624 Contact: László Mangel, MD | +36 30 245 7110 | laszlo.mangel@aok.pte.huPrincipal Investigator: László Mangel, MD Recruiting |
| Szegedi Tudományegyetem Onkoterápiás Klinika | Szeged, Hungary, 6720 Contact: Katalin Hideghéty | 36 30 292 1638 | katalin.hideghety@gmail.comPrincipal Investigator: Katalin Hideghéty, MD, PhD Recruiting |
| Vas Megyei Markusovszky Lajos Általános Rehabilitációs és Gyógyfürdő Kórház, Egyetemi Oktatókórház Nonprofit Zrt | Szombathely, Hungary, 9700 Contact: Miklós Wenczl, MD | +36 30 600 3359 | wenczl.miklos@markusovszky.huPrincipal Investigator: Miklós Wenczl, MD Recruiting |
| City Cancer Centre, Vijayawada | Vijayawada, Andhra Pradesh, India, 520002 Active, not recruiting |
| HCG - Bangalore Institute of Oncology, Bangalore | Bengaluru, Karnataka, India, 560027 Active, not recruiting |
| Amrita Institute of Medical Sciences and Research Centre, Kochi | Kochi, Kerala, India, 682 026 Active, not recruiting |
| Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram | Thiruvananthapuram, Kerala, India, 695 011 Active, not recruiting |
| Marathwada Regional Cancer Centre and Research Institute - Government | Aurangabad, Maharashtra, India, 431001 Contact: Shewalkar Balaji, M.D., DNB | 91 9850632639 | bkrish_e@rediffmail.comPrincipal Investigator: Shewalkar Balaji, M.D., DNB Not yet recruiting |
| Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute | Andheri-West, Mumbai, India, 400 053 Contact: Anandh Balasubramaniam, MCh. | 91-9324599906Principal Investigator: Anandh Balasubramaniam, MCh Not yet recruiting |
| Tata Memorial Hospital , Mumbai | Parel, Mumbai, India, 400012 Active, not recruiting |
| Indraprastha Apollo Hospital, New Delhi | Jasola Viha, New Delhi, India, 110076 Active, not recruiting |
| Sahyadri Hospitals Limited | Erandauame, Pune, India, 411004 Active, not recruiting |
| Dr. Rai Memorial Medical Centre, Chennai | Chennai, Tamil Nadu, India, 600018 Active, not recruiting |
| HCG Shanti Mukand Hospital - Curie Cancer Centre, Delhi | Delhi, India, 110092 Contact: Munish Gairola, MD | 91 9958 431 596 | gairolam@hotmail.comPrincipal Investigator: Munish Gairola, MD Not yet recruiting |
| Soroka University M.C. | Beer-Sheva, Israel, 84101 Contact: Konstantin Lavrenkov, Dr | +972 (0) 86244127 | KonstantinL@clalit.org.ilPrincipal Investigator: Konstantin Lavrenkov, Dr Recruiting |
| Rambam Health Care Campus | Haifa, Israel, 3109601 Contact: Tzahala Tzuk Shina, Dr | +972-4-8543811 | t_shina@rambam.health.gov.ilPrincipal Investigator: Tzahala Tzuk Shina, Dr Recruiting |
| Hadassah Medical Center | Jerusalem, Israel, 91120 Contact: Alexander Lossos, MD | +972-50-8946874 | ALOS@hadassah.org.ilPrincipal Investigator: Alexander Lossos, MD Recruiting |
| SHEBA Medical Center | Tel Hashomer, Israel, 52126 Contact: Leor Zach, MD | 912-3-530 2290 | Leor.zach@sheba.health.gov.ilPrincipal Investigator: Leor Zach, MD Recruiting |
| Tel-Aviv Sourasky Medical Center | Tel-Aviv, Israel, 64239 Contact: Deborah T Blumenthal, MD | +972 3 6973494 | deborahblumenthal@gmail.comPrincipal Investigator: Deborah T Blumenthal, MD Recruiting |
| UO Oncologie Medica Dipartimento Oncologico | Bologna, Italy, 40139 Contact: Alba Brandes, MD | +390516225697 | a.brandes@ausi.bo.itPrincipal Investigator: Alba Brandes, MD Recruiting |
| Fondazione IRCCS Instituto Neurologico Carlo Besta | Milano, Italy, 20133 Contact: Gaetano Finocchiaro, MD | +39 02 23942454 | gaetano.finocchiaro@istituto-besta.itPrincipal Investigator: Gaetano Finocchiaro, MD Recruiting |
| Sacred Heart Catholic University | Rome, Italy, 00168 Contact: Silvia Chiesa, MD | +39 33 84 35 7241 | silvia.chiesa@gmail.comPrincipal Investigator: Mario Balducci, MD Recruiting |
| Universita e AO Citta delia Scienza, Universita Di Torino | Torino, Italy, 10126 Contact: Riccardo Soffietti, MD | +39 011 633 4904 | riccardo.soffietti@unito.itPrincipal Investigator: Riccardo Soffietti, MD Recruiting |
| Grupo Médico Camino S.C. | Mexico, D.F, Mexico, 03310 Contact: Freddy Guillermo Castro Farfán, MD | 52 (55) 4168 9873 | guillermocastrof@gmail.comPrincipal Investigator: Freddy Guillermo Castro Farfán, MD Recruiting |
| Hospital Civil de Guadalajara "Fray Antonio Alcalde" | Guadalajara, Jalisco, Mexico, 34000 Contact: Francisco Javier Ramírez Godínez,, MD | 52 33 36 140482 | drpacoramirez@yahoo.com.mxPrincipal Investigator: Francisco Javier Ramírez Godínez,, MD Recruiting |
| Ensayos Clínicos y Medicina de Alta Especialidad, S.C. | Culiacán, Sinaloa, Mexico, 80020 Contact: José Ángel Félix Torrontegui, MD | 52 667 758 7952 | angel_f_t@hotmail.comPrincipal Investigator: José Ángel Félix Torrontegui, MD Recruiting |
| Servicios Medicos de Investigacion Clinica Sc | Durango, Mexico, 34000 Contact: Jesús López Hernández,, MD | 52 618 1858977 | jlh_durango@yahoo.com.mxPrincipal Investigator: Jesús López Hernández, MD Recruiting |
| Hospital Central "Ignacio Morones Prieto" | San Luis Potosí, Mexico, 78240 Contact: Ildefonso Rodríguez Leyva, MD | 52 444 817 6692 | ilrole@yahoo.com.mxPrincipal Investigator: Ildefonso Rodríguez Leyva, MD Recruiting |
| Medisch Centrum Haaglanden | The Hague, Zuid Holland, Netherlands, 2512 VA Contact: M J Vox, MD | +31 7033 02 508 | m.vos@mchaaglanden.nlPrincipal Investigator: Maaike Vos, MD Recruiting |
| VUMC | Amsterdam, Netherlands, 1081HV Contact: Myra van Linde, MD | +31 (0) 20 4444 321 | m.vanlinde@VUMC.nlPrincipal Investigator: Myra van Linde, MD Recruiting |
| Radboud University Nijmegen Medical Center | Nijmegen, Netherlands, 6525 GA Contact: Sasja Mulder, MD | +31 24 3655388 | s.mulder@onco.umcn.nlPrincipal Investigator: Sasja Mulder, MD Recruiting |
| Christchurch Hospital | Christchurch Central, Christchurch, New Zealand, 8011 Contact: Bridget A Robinson, BMed Sci MBChB FRACP | 64-3-394-0020 | bridget.robinson@cdhb.govt.nzPrincipal Investigator: Bridget A Robinson, BMed Sci MBChB FRACP Recruiting |
| Palmerston North Hospital | Roslyn, Palmerston North, New Zealand, 4414 Contact: Claire Hardie, BSc (Hons) MBChB MRCP FRCR | 64 6350 8430 | claire.hardie@midcentraldhb.govt.nzPrincipal Investigator: Claire Hardie, BSc (Hons) MBChB MRCP FRCR Recruiting |
| Waikato Hospital, Regional Cancer Centre | Hamilton, Waikato District, New Zealand, 3240 Contact: Michael R Tills, MBChB DRACR | 64-7-839-8976 | Michael.Tills@waikatodhb.health.nzPrincipal Investigator: Michael Tills, MBChB DRACR Recruiting |
| Hospital Almanzor Aguinaga Asenjo | Chiclayo, Peru Contact: Rodrigo Auqui, MD | (+51) 979-928-159 | roaflo@yahoo.esPrincipal Investigator: Rodrigo Auqui, MD Recruiting |
| Instituto Oncologico Miraflores | Lima, Peru, Lima 18 Contact: PEDRO RIOS | (51) 990899299 | omarivers@hotmail.comPrincipal Investigator: Fernando Salas, MD Recruiting |
| Clinica Anglo Americana | Lima, Peru, Lima 27 Contact: Claudia Lozada, MD | (+51) 997-921-444 | clalozada@yahoo.comPrincipal Investigator: Claudia Lozada, MD Recruiting |
| Clinica Ricardo Palma | Lima, Peru, Lima 27 Contact: Wuilbert Rodriguez, MD | (+51) 993-513-544 | oncologiawrp@yahoo.esPrincipal Investigator: Wuilbert Rodriguez, MD Recruiting |
| Oncosalud | Lima, Peru, Lima 41 Contact: Carlos O Munive, MD | (+51) 964-646451 | carlosmunive@hotmail.comPrincipal Investigator: Carlos O Munive, MD Recruiting |
| Institut Catala d Oncologia | LaHospitalet de Lubregat, Catalonia, Spain, 08908 Contact: Miguel Gil-Gil, MD | +34 93 260 7744 | mgilgil@icomcologia.netPrincipal Investigator: Manuel Gil-Gil, MD Recruiting |
| Dra. Sonia Del Barco Berron, ICO Girona Avda, | Franca, Girona, Spain, 17007 Contact: Sonia Del Barco Berron, MD | 972225834 | sdel@iconcologia.netPrincipal Investigator: Sonia Del Barco Berron, MD Recruiting |
| Hospital Clinic | Barcelona, Spain, 8036 Contact: Estela Pineda, MD | +93 2275402 | epineda@clinic.ub.esPrincipal Investigator: Estela Pineda, MD Recruiting |
| ICO Badalona-Hospital Germans Trias i Pujol | Barcelonia, Spain, 08916 Contact: Carmen Balana, MD | +34 93 497 89 24/5 | cbalana@iconcologia.netPrincipal Investigator: Carmen Balana, MD Recruiting |
| Hospital 12 de Octubre | Madrid, Spain, 28041 Contact: Juan Manuel Sepulveda Sanchez, Dr | +34913908003 | jmsepulveda76@gmail.comPrincipal Investigator: Juan Manuel Sepulveda Sanchez, Dr Recruiting |
| Kantonsspital Aarau Medizinische Onkologie Tellstrasse | Aarau, AG, Switzerland, 5001 Contact: Christoph Mamot, MD | ++41 62 838 60 53 | christoph.mamot@ksa.chPrincipal Investigator: Christoph Mamot, MD Recruiting |
| CHUV, Centre Hospitalier Universitaire Vaudois | Lausanne, VD, Switzerland, 1011 Contact: Andreas F Hottinger, MD, PhD | +41 21 314 0168 | andreas.hottinger@chuv.chPrincipal Investigator: Andreas F Hottinger, MD, PhD Recruiting |
| Oncology Institute of Southern Switzerland (IOSI) | Bellinzona, Switzerland, 6500 Contact: Jolanda de Jong, SRn | +41 91 811 8945 | jolanda.dejong@eoc.chPrincipal Investigator: Gianfranco Pesce, MD Recruiting |
| Inselspital, Universitatsspital Bern, Universitatsklinik fur Medizinische Onkologie, Freiburgstrasse | Bern, Switzerland, 3010 Contact: Andrea Schmid, MD | +41 31 632 41 15 | andrea.schmid@insel.chPrincipal Investigator: Andrea Schmid, MD Recruiting |
| Hopitaux Universitaires de Geneve-HUG-Centre d'Oncologie | Geneva, Switzerland, 1211 Contact: Pierre-Yves Dietrich, MD, PhD. | +41 22 372 32 70 | Ouerre-Yves.Detrich@hcuge.chPrincipal Investigator: Pierre-Yves Dietrich, MD, PhD. Recruiting |
| Brain Tumor Center, University Hospital Zurich | Zurich, Switzerland, 8091 Contact: Michael Weller, MD | +41 44 2555500 | michael.weller@usz.chPrincipal Investigator: Michael Weller, MD Recruiting |
| National Cheng Kung University Hospital | Tainan City, Bei District, Taiwan, 704 Contact: E-Jian Lee, M.D. PhD | 886- 6-23535355204 | ejian@mail.ncku.edu.twPrincipal Investigator: E-Jian Lee, M.D. PhD Recruiting |
| Kaohsiung Chang Gung Memorial Hospital | Kaohsiung, Taiwan, 83301 Contact: Jih-Tsun Ho, MD | 886- 7-731-71238011 | jihtsunho@yahoo.com.twPrincipal Investigator: Jih-Tsun Ho, MD Recruiting |
| Chang Gung Memorial Hospital Linkou Branch | Taichung, Taiwan, 40705 Contact: Cheng-Neng Chang, MD | 886- 3-328-1200 | justin@mail.cgu.edu.twPrincipal Investigator: Cheng-Neng Chang, MD Recruiting |
| Taichung Veterans General Hospital | Taichung, Taiwan, 40705 Contact: Wen-Yu Cheng, MD | 886- 4-2359-25255081 | wycheng@vghtc.gov.twPrincipal Investigator: Wen-Yu Cheng Recruiting |
| Chi Mei Medical Center | Tainan City - Yongkang District, Taiwan, 710 Contact: Chin-Hong Chang, MD | 886 6-281281157112 | cmh7520@gmail.comPrincipal Investigator: Chang Chin-Hong Recruiting |
| Tri-Service General Hospital | Taipei city - Neihu District, Taiwan, 00114 Contact: Hsin-I Ma, MD, PhD | 886- 2-87927177 | uf004693@mail2000.com.twPrincipal Investigator: Hsin-I Ma Recruiting |
| National Taiwan University Hospital | Taipei City - Zhongzheng Dist, Taiwan, 00100 Contact: Ms Chieh-Ying Lan | 886 915 283 373 | lan8882@gmail.comPrincipal Investigator: Ham-Min Tseng, MD Recruiting |
| Siriraj Hospital | Bangkok, Bangkok Noi, Thailand, 10700 Contact: Sith Sathornsumetee, MD | 66 81 812 7830 | drsith@gmail.comPrincipal Investigator: Sith Sathornsumetee, MD Recruiting |
| Maharaj Nakorn Chiang Mai Hospital | Mueang Chiangmai, Chiang Mai, Thailand, 50200 Contact: Kanokwan Kanokwan, MD | 66 816 811 910 | watcharasaksilp@gmail.comPrincipal Investigator: Kanokwan Watcharasaksilp, MD Recruiting |
| King Chulalongkorn Memorial Hospital | Bangkok, Pathumwan, Thailand, 10330 Contact: Iyavut Thaipisuttikul, MD | 66 81 938 7087 | iyavut@gmail.comPrincipal Investigator: Iyavut Thaipisuttikul, MD Recruiting |
| Prince of Songkhla University Hospital | Hat Yai, Songkhla, Thailand, 90110 Contact: Arundee Dechaphunkul, MD | MD 66 74 451469 | dearunee@medicine.psu.ac.thPrincipal Investigator: Arundee Dechaphunkul, MD Recruiting |
| Royal Marsden NHS Foundation Trust | Sutton, Surrey, United Kingdom, SM2 5PT Contact: Kathy Greenwood | 0208-661-3300 | Kathy.greenwood@rmh.nhs.ukPrincipal Investigator: Frank Saran, MD, FRCR Recruiting |
| The Bristol Haematology and Oncology Centre | Bristol, United Kingdom, BS2 8ED Contact: Kirsten Hopkins, MD | 44 0117 342 3008 | Kirsten.Hopkins@UHBristol.nhs.ukPrincipal Investigator: Kirsten Hopkins, MD Recruiting |
| Edinburgh Cancer Centre Western General Hospital | Edinburgh, United Kingdom, EH4 2XU Contact: Sara Erridge, Dr. | +44 (0) 131 537 1052 | serridge@staffmail.ed.ac.ukPrincipal Investigator: Sara Erridge, Dr Recruiting |
| Beatson West of Scotland Cancer Centrel | Glasgow, United Kingdom, G12 0NY Contact: Anthony Chalmers, Professor | +44 (0) 141 301 7097 | Anthony.Chalmers@glasgow.ac.ukPrincipal Investigator: Anthony Chalmers, Professor Recruiting |
| Guy's and St Thomas' NHS, Westminister Bridge Road | London, United Kingdom, SE17EH Contact: Kelly Radford, RN | 020 7188 2020 | kelly.radford@gstt.nhs.ukPrincipal Investigator: Ronald Beaney, MD Recruiting |
| Nottingham City Hospital | Nottingham, United Kingdom, NG5 1PB Contact: Karen Foweraker, Dr | +44 0115969 1169 | Karen.Foweraker@nuh.nhs.ukRecruiting |