Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure
Overview[ - collapse ][ - ]
| Purpose | The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity. Both could influence exercise capacity in normoxic as well as hypoxic conditions. |
|---|---|
| Condition | Chronic Heart Failure |
| Intervention | Drug: carvedilol Drug: bisoprolol Drug: Nebivolol |
| Phase | Phase 4 |
| Sponsor | Centro Cardiologico Monzino |
| Responsible Party | Centro Cardiologico Monzino |
| ClinicalTrials.gov Identifier | NCT00517725 |
| First Received | August 16, 2007 |
| Last Updated | September 15, 2010 |
| Last verified | September 2010 |
Tracking Information[ + expand ][ + ]
| First Received Date | August 16, 2007 |
|---|---|
| Last Updated Date | September 15, 2010 |
| Start Date | July 2007 |
| Estimated Primary Completion Date | May 2010 |
| Current Primary Outcome Measures | exercise capacity [Time Frame: two months] |
| Current Secondary Outcome Measures | lung diffusion [Time Frame: two months] |
Descriptive Information[ + expand ][ + ]
| Brief Title | Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure |
|---|---|
| Official Title | Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function |
| Brief Summary | The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity. Both could influence exercise capacity in normoxic as well as hypoxic conditions. |
| Detailed Description | Not Provided |
| Study Type | Interventional |
| Study Phase | Phase 4 |
| Study Design | Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment |
| Condition | Chronic Heart Failure |
| Intervention | Drug: carvedilol Drug: bisoprolol Drug: Nebivolol |
| Study Arm (s) |
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Recruitment Information[ + expand ][ + ]
| Recruitment Status | Completed |
|---|---|
| Estimated Enrollment | 60 |
| Estimated Completion Date | May 2010 |
| Estimated Primary Completion Date | Not Provided |
| Eligibility Criteria | Inclusion Criteria: - Chronic heart failure patients in stable clinical condition Exclusion Criteria: - No comorbidity - NYHA class IV |
| Gender | Both |
| Ages | 18 Years |
| Accepts Healthy Volunteers | No |
| Contacts | Not Provided |
| Location Countries | Italy |
Administrative Information[ + expand ][ + ]
| NCT Number | NCT00517725 |
|---|---|
| Other Study ID Numbers | R76-CCM S78/407 |
| Has Data Monitoring Committee | No |
| Information Provided By | Centro Cardiologico Monzino |
| Study Sponsor | Centro Cardiologico Monzino |
| Collaborators | Not Provided |
| Investigators | Principal Investigator: Piergiuseppe Agostoni, MD, PhD Centro Cardiologico MonzinoStudy Chair: Giancarlo Marenzi, MD Centro Cardiologico Monzino |
| Verification Date | September 2010 |
Locations[ + expand ][ + ]
| Centro Cardiologico Monzino, University of Milan | Milan, Italy, 20138 |
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