Taltz

Taltz treats moderate-to-severe plaque psoriasis (a skin condition characterized by raised, red patches covered with flaky, silvery scales) and active psoriatic arthritis.

Taltz Overview

Reviewed: March 23, 2016
Updated: 

Taltz is a prescription medication used to treat moderate-to-severe plaque psoriasis and active psoriatic arthritis. It belongs to a group of drugs called interleukin blockers. These drugs work by blocking the inflammatory process that is responsible for the development of plaque psoriasis and active psoriatic arthritis.

Taltz comes in an autoinjector and a prefilled syringe that you or your caregiver may use at home to give injections. Taltz is injected just under your skin (subcutaneous injection), in your thighs, stomach area, or the back of your arm, by you or a caregiver. 

Common side effects include injection site reactions, upper respiratory tract infections, and nausea. 

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Taltz Cautionary Labels

precautionsprecautions

Uses of Taltz

Taltz is a prescription medication used to treat adults:

  • with moderate to severe plaque psoriasis and who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet or UV light)
  • with active psoriatic arthritis (can be used alone or with the medicine methotrexate)

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Taltz Drug Class

Taltz is part of the drug class:

Side Effects of Taltz

Taltz may cause serious side effects. See "Drug Precautions".

Common side effects include:

  • injection site reactions
  • upper respiratory infections
  • fungal infections
  • nausea

This is not a complete list of Taltz side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Taltz Interactions

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take:

  • warfarin (Coumadin, Jantoven)
  • cyclosporine

Tell your healthcare provider if you are planning to receive any "live" vaccines such as chickenpox vaccine (Varicella), nasal vaccine for influenza (FluMist), measles, mumps, rubella vaccine (MMR), Polio vaccine, Rotavirus vaccine, Smallpox vaccine, Yellow fever vaccine, BCG vaccine. If you receive a "live vaccine" while taking Taltz, you may become infected with the bacteria or virus contained in the vaccine.

This is not a complete list of drug interactions. Keep a list of all your medicines with you to show your healthcare provider and pharmacist each time you get a new medicine. Ask your healthcare provider if you are not sure if your medicine is one listed above.

Taltz Precautions

Serious side effects have been reported with Taltz including the following:

  • Serious allergic reactions. If you have a severe allergic reaction, do not give another injection of Taltz. Get emergency medical help right away if you get any of the following symptoms of a serious allergic reaction:
    • feel faint
    • swelling of your face, eyelids, lips, mouth, tongue, or throat
    • trouble breathing or throat tightness
    • chest tightness
    • skin rash
  • Crohn’s disease or ulcerative colitis (Inflammatory bowel disease) can happen during treatment with Taltz, including worsening symptoms. Tell your healthcare provider if you have new or worsening symptoms of inflammatory bowel disease during treatment, including:
    • stomach pain
    • diarrhea with or without blood
    • weight loss
  • Infections: Serious infections have happened. If you experience any signs of symptoms of an infection, contact your healthcare provider. Signs and symptoms of infections are: 
    • fever, sweats, or chills
    • muscle aches
    • cough
    • shortness of breath
    • blood in your phlegm (mucus)
  • Tuberculosis (TB) infection. This medication may affect your immune system. Taltz may lower the ability of your immune system to fight infections and may increase your risk of infections, which can become serious.
    • Your healthcare provider should check you for tuberculosis (TB) before you start treatment with Taltz.
    • Your healthcare provider may treat you with medicine for TB before you begin treatment with Taltz if you have a past history of TB or have TB.
    • Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with Taltz.

Before receiving Taltz, tell your tell your healthcare provider if you recently received or are scheduled to receive an immunization (vaccine). It is not recommended you receive live vaccines during treatment with Taltz. In addition, your healthcare provider may need to schedule certain vaccines before you start receiving Taltz. 

Do not use Taltz if you have had a severe allergic reaction to Taltz or any of the other inactive ingredients.

Taltz Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Taltz, there are no specific foods you must exclude from your diet when receiving this medication.

Inform MD

Before using Taltz, tell your healthcare provider about all of your medical conditions, including if you:

  • are allergic to Taltz or to any of its ingredients
  • are being treated for an infection
  • have an infection that does not go away or that keeps coming back
  • have TB or have been in close contact with someone with TB
  • think you have an infection or have symptoms of an infection
  • have Crohn’s disease or ulcerative colitis
  • have recently received or are scheduled to receive an immunization (vaccine). It is not recommended you receive live vaccines during treatment with Taltz.
  • are pregnant or plan to become pregnant. It is not known if this medicine can harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if this medicine passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Taltz and Pregnancy

Before using Taltz, tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if this medicine can harm your unborn baby.

Taltz and Lactation

Before using Taltz, tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if this medicine passes into your breast milk.

Taltz Usage

Use this medication exactly as prescribed by your healthcare provider.

  • If your healthcare provider decides that you or a caregiver may give your injections of Taltz at home, you should receive training on the right way to prepare and inject Taltz. Do not try to inject yourself, until you or your caregiver have been shown how to inject Taltz.
  • Taltz comes in an autoinjector and a prefilled syringe that you or your caregiver may use at home to give injections. Your healthcare provider will decide which type of Taltz is best for you to use at home.
  • Taltz is given as an injection under your skin (subcutaneous injection), in your thighs or stomach area (abdomen) by you or a caregiver. A caregiver may also give you the injection of Taltz in the back of your arm.
  • Do not give an injection in an area of the skin that is tender, bruised, red or hard, or in an area of skin that is affected by psoriasis.
  • Each injection should be given at an alternate site. Do not use the one-inch area around your navel (belly button).

If you forget to take your dose:

  • Do not miss any doses unless your healthcare provider says it is okay. If you forget to take your dose, inject a dose as soon as you remember. Then, take your next dose at your regular scheduled time.
  • If you inject more Taltz than prescribed, call your healthcare provider or go to the nearest emergency room right away.

Taltz Dosage

The recommended dose for plaque psoriasis is Taltz (ixekizumab) 160 mg (two 80 mg injections) at Week 0, followed by 80 mg at Weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks.

The recommended dose for psoriatic arthritis is Taltz (ixekizumab) 160 mg (two 80 mg injections) at Week 0, followed by 80 mg every 4 weeks.

For those with psoriatic arthritis and moderate-to-severe plaque psoriasis, the recommended dose is Taltz (ixekizumab) 160 mg (two 80 mg injections) at Week 0, followed by 80 mg at Weeks 2, 4, 6, 8, 10, and 12, then 80 mg every 4 weeks.

Taltz Overdose

If you take too much Taltz, call your healthcare provider or local Poison Control Center right away.

Other Requirements

  • Store Taltz in the refrigerator between 36°F to 46°F (2°C to 8°C).
  • Protect from light.
  • Do not freeze. Do not use if Taltz has been frozen.
  • Do not shake the injection.

Keep all medicines out of the reach of children and pets.