Rebinyn

Rebinyn is a prescription medication used to treat hemophilia B in children and adults, a hereditary bleeding disorder caused by a lack of blood clotting factor IX.

Rebinyn belongs to a group of drugs called coagulation recombinant Factor IX products. These help by replacing a protein required for blood clotting and stop bleeding. 

This medication comes in solution form to be infused into a vein by a healthcare professional.

Common side effects of Rebinyn include itching and injection site reactions, such as warmth, redness, and tenderness at the injection site.

Rebinyn is a prescription medication used to treat hemophilia B, a hereditary bleeding disorder caused by a lack of blood clotting factor IX.

Rebinyn is used to 

• Control bleeding episodes
• Manage bleeding events before, during, and after surgical procedures

Rebynin is not used for prevention of bleeding episodes or induction of immune tolerance (a procedure used to prevent the immune system from rejecting foreign substances like blood products).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

• Novo Nordisk, Inc.

Serious side effects have been reported with Rebinyn. See the “Rebinyn Precautions” section.

Common side effects of Rebynin include the following:

• itching
• injection site reactions such as redness, warmth, and tenderness

This is not a complete list of Rebinyn side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effects that bother you or that do not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

No drug interactions have been determined by the manufacturer. However, you should tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Not all drug interactions are known or reported and new drug interactions are continually being reported.

Serious side effects have been reported with Rebinyn including the following: 

• Severe allergic reactions. Allergic-type hypersensitivity reactions, including anaphylaxis, are possible with Rebinyn.  Stop using Rebinyn and contact your doctor if following symptoms occur: hives, chest tightness, wheezing, and hypotension.
• Formation of inhibitors to Factor IX (neutralizing antibodies) may occur when on Rebinyn. Your doctor will suggest a laboratory test (Bethesda assay) If bleeding is not controlled with the recommended dose of Rebinyn, or when factor IX plasma activity is below the expected level.
• Blood Clots. Tell your healthcare provider right away if you have some or all of the following symptoms of a blood clot that has formed in the lungs:
  • difficulty breathing
  • rapid breathing, fast heartbeat and chest pain especially with inhalation
  • anxiety
  • coughing up of blood
• Kidney problems. 

Do not take Rebinyn if you are allergic to Rebinyn or to any of its ingredients.

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Rebinyn, there are no specific foods that you must exclude from your diet when receiving this medication.

Before taking Rebinyn, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

• are allergic to Rebinyn or to any of its ingredients
• have kidney problems
• have or have previously had thrombotic events
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tell your doctor if you are pregnant or plan to become pregnant. 

No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Rebinyn should be given to a pregnant woman only if clearly needed.

Tell your doctor if you are breastfeeding or plan to breastfeed. 

It is not known if Rebinyn crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Rebinyn.

Take Rebinyn exactly as prescribed.

This medication is available in an injectable form to be infused into a vein (IV) by a healthcare professional.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age

The recommended dose of Rebinyn for the treatment of bleeding episodes is 40 IU/kg for minor or moderate type of bleeding and 80 IU/kg for major type. Additional doses of 40 IU/kg can be given. 

The recommended dose of Rebinyn for the treatment of bleeding episodes related to surgical procedures is 40 IU/kg for minor type of surgical procedure and 80 IU/kg for major type. This dose is infused before the procedure. Additional doses of 40 IU/kg can be given in 1-3 days intervals within the first week after major surgery.

If Rebinyn is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if an overdose is suspected, seek emergency medical attention.