Mitigare

Mitigare is used to prevent gout attacks. Mitigare can cause diarrhea.

Mitigare Overview

Reviewed: January 21, 2015
Updated: 

Mitigare is a prescription medication used to prevent gout attacks. Mitigare belongs to a group of drugs called antigout agents. It is thought to work by inhibiting the activity of neutrophils (inflammatory cells), which results in the reduction of inflammation and the symptoms of gout.

Mitigare comes in capsule form and is usually taken once or twice daily.
 
Common side effects of Mitigare include nausea, vomiting, and diarrhea.

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Mitigare Cautionary Labels

precautionsprecautions

Uses of Mitigare

Mitigare is a prescription medicine used to prevent treat gout flares in adults.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Mitigare Drug Class

Mitigare is part of the drug class:

Side Effects of Mitigare

Mitigare can cause serious side effects or even cause death. Get medical help right away, if you have:

  • Muscle weakness or pain
  • Numbness or tingling in your fingers or toes
  • Unusual bleeding or bruising
  • Increased infections
  • Feel weak or tired
  • Pale or gray color to your lips, tongue, or palms of your hands
  • Severe diarrhea or vomiting

Common side effects:

  • diarrhea (most common)
  • nausea
  • vomiting
  • abdominal pain

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of Mitigare. For more information, ask your healthcare provider or pharmacist.

Mitigare Interactions

Tell your doctor about all the medicines you take, including ones that you may only be taking for a short time, such as antibiotics.  Especially tell your doctor if you are taking:

  • atazanavir sulfate (Reyataz)
  • clarithromycin (Biaxin)
  • cyclosporine (Neoral, Gengraf, Sandimmune)
  • darunavir (Prezista)
  • fosamprenavir (Lexiva) with ritonavir
  • fosamprenavir (Lexiva)
  • indinavir (Crixivan)
  • itraconazole (Sporanox)
  • ketoconazole (Nizoral)
  • Iopinavir/ritonavir (Kaletra)
  • nefazodone (Serzone)
  • nelfinavir mesylate(Viracept)
  • ritonavir (Norvir)
  • saquinavir mesylate (Invirase)
  • telithromycin (Ketek)
  • tipranavir (Aptivus)

Do not start a new medicine without talking to your doctor.

This is not a complete list of Mitigare drug interactions.  Ask your doctor or pharmacist for more information.

Mitigare Precautions

Mitigare can cause serious side effects or death if levels of Mitigare are too high in your body.

  • Taking certain medicines with Mitigare can cause your level of Mitigare to be too high, especially if you have kidney or liver problems.
  • Tell your doctor about all your medical conditions, including if you have kidney or liver problems. Your dose of Mitigare may need to be changed.
  • Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements.
  • Even medicines that you take for a short period of time, such as antibiotics, can interact with Mitigare and cause serious side effects or death.
  • Talk to your doctor or pharmacist before takng any new medicine.
  • See "Drug Interactions"

Do not take Mitigare if you have liver or kidney problems and you take certain other medicines. Serious side effects, including death, have been reported in these patients even when taken as directed.

Mitigare Food Interactions

Avoid eating grapefruit or drinking grapefruit juice while taking Mitigare. It can increase your chances of getting serious side effects.

Inform MD

Before you take Mitigare tell your doctor about all your medical conditions including if you:

  • have liver or kidney problems
  • are pregnant or plan to become pregnant. It is not known if Mitigare will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. Mitigare passes into your breast milk. You and your doctor should decide if you will take Mitigare or breastfeed. If you take Mitigare and breastfeed, you should talk to your child's doctor about how to watch for side effects in your child.

Tell your doctor about all the medicines you take, including ones that you may only be taking for a short time, such as antibiotics. Do not start a new medicine without talking to your doctor. Using Mitigare with certain other medicines, such as cholesterol-lowering medications and digoxin, can affect each other causing serious side effects. Your doctor may need to change your dose of Mitigare. Talk to your doctor about whether the medications you are taking might interact with Mitigare, and what side effects to look for.

Mitigare and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Mitigare and Lactation

Tell your doctor if you are breastfeeding or if you plan to breastfeed. Mitigare is excreted in human breast milk. It is not known if Mitigare will harm your baby.

Mitigare Usage

  • Take Mitigare exactly as your healthcare provider tells you to take it. If you are not sure about your dosing, call your healthcare provider.
  • Mitigare can be taken with or without food.
  • If you take too much Mitigare go to the nearest hospital emergency room right away.
  • Do not stop taking Mitigare even if you start to feel better, unless your healthcare provider tells you.
  • Your healthcare provider may do blood tests while you take Mitigare.
  • If you take Mitigare daily and you miss a dose, then take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take 2 doses at the same time.
  • If you have a gout flare while taking Mitigare daily, report this to your healthcare provider.

Mitigare Dosage

Take Mitigare exactly as your doctor prescribes it. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you.

Typical dose of Mitigare for prevention of gout flares is 0.6 mg (1 capsule ) once or twice daily in patients over 16 years of age.  Maximum daily dose is 1.2 mg (2 tablets or 2 capsules) per day.

Mitigare Overdose

If you take too much Mitigare call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Mitigare is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Keep Mitigare at 20° to 25°C (68° to 77°F).
  • Keep Mitigare in tightly sealed container, out of the light.
  • Keep this and all medicines out of the reach of children.