Depo-Estradiol

treats symptoms associated with menopause such as hot flashes. It also treats women whose ovaries do not produce enough estrogen.

Depo-Estradiol Overview

Reviewed: September 19, 2012
Updated: 

Depo-Estradiol is a prescription medication used to treat symptoms of menopause including hot flashes and vaginal dryness. It is also used to treat conditions in which a woman's ovaries do not produce enough estrogen naturally (hypoestrogenism).

Depo-Estradiol is a form of the hormone estrogen. It replaces estrogen that is not naturally produced by the ovaries.

This medication is available in an injectable form to be given directly into a muscle (IM) by a healthcare professional.

Common side effects of Depo-Estradiol include 

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What are you taking Depo-estradiol for?

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  • Other
  • Hot Flashes
  • Hypogonadism
  • Menopause, Premature
  • Menorrhagia
  • Osteoporosis, Postmenopausal
  • Primary Ovarian Insufficiency
  • Prostatic Neoplasms

How long have you been taking it?

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  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did Depo-estradiol work for you?

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Depo-Estradiol Cautionary Labels

precautionsprecautions

Uses of Depo-Estradiol

Depo-Estradiol is a prescription medication used to treat symptoms of menopause including hot flashes and vaginal dryness. It is also used to treat conditions in which a woman's ovaries do not produce enough estrogen naturally (hypoestrogenism).

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Depo-Estradiol Drug Class

Depo-Estradiol is part of the drug class:

Side Effects of Depo-Estradiol

Serious side effects have been reported with Depo-Estradiol. See the “Drug Precautions” section.

Common side effects of Depo-Estradiol include the following:

  • headache
  • breast pain or tenderness
  • nausea
  • vomiting
  • constipation
  • gas
  • heartburn
  • weight gain or loss
  • hair loss
  • swelling or itching of the vagina
  • vaginal discharge
  • painful menstrual periods
  • anxiety
  • depression
  • changes in mood
  • change in sexual desire
  • back, neck, or muscle pain
  • runny nose or congestion
  • cough
  • unwanted hair growth
  • difficulty wearing contact lenses

This is not a complete list of Depo-Estradiol side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Depo-Estradiol Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Amiodarone (Cordarone, Pacerone)
  • Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
  • Aprepitant (Emend)
  • Carbamazepine (Carbatrol, Epitol, Tegretol)
  • Cimetidine (Tagamet)
  • Clarithromycin (Biaxin)
  • Cyclosporine (Neoral, Sandimmune)
  • Dexamethasone (Decadron, Dexpak)
  • Diltiazem (Cardizem, Dilacor, Tiazac, others)
  • Erythromycin (E.E.S, Erythrocin)
  • Fluoxetine (Prozac, Sarafem)
  • Fluvoxamine (Luvox)
  • Griseofulvin (Fulvicin, Grifulvin, Gris-PEG)
  • Lovastatin (Altocor, Mevacor)
  • Medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), delaviridine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), lopinavir (in Kaletra),nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase)
  • Medications for thyroid disease
  • Nefazodone
  • Other medications that contain estrogen
  • Phenobarbital
  • Phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin)
  • Rifampin (Rifadin, Rimactane, in Rifamate)
  • Sertraline (Zoloft)
  • Troleandomycin (TAO)
  • Verapamil (Calan, Covera, Isoptin, Verelan)
  • Zafirlukast (Accolate)
  • St. John's Wort

This is not a complete list of Depo-Estradiol drug interactions. Ask your doctor or pharmacist for more information.

Depo-Estradiol Precautions

Serious side effects have been reported with Depo-Estradiol including the following:

  • bulging eyes
  • yellowing of the skin or eyes
  • itching
  • loss of appetite
  • fever
  • joint pain
  • stomach tenderness, pain, or swelling
  • movements that are difficult to control
  • hives
  • rash or blisters on the skin
  • swelling, of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
  • hoarseness
  • wheezing
  • difficulty breathing or swallowing

Do not use Depo-Estradiol if you:

  • are allergic to estradiol or to any of its ingredients
  • have abnormal vaginal bleeding
  • have a known or suspected history of breast cancer
  • have a known or suspected estrogen-dependent cancer
  • have a history of blood clots
  • have liver disease
  • are pregnant or possibly pregnant

Depo-Estradiol Food Interactions

Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Inform MD

Before using Depo-Estradiol tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to estradiol or to any of its ingredients
  • have or have ever had asthma
  • have seizures
  • have migraine headaches
  • have endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body)
  • have uterine fibroids (growths in the uterus that are not cancer)
  • have or have had yellowing of the skin or eyes, especially during pregnancy or while you were using an estrogen product
  • have very high or very low levels of calcium in your blood
  • have porphyria (condition in which abnormal substances build up in the blood and cause problems with the skin or nervous system) or gallbladder, thyroid, pancreas, liver or kidney disease
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Depo-Estradiol and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Depo-Estradiol falls into category X. Depo-Estradiol should now be used during pregnancy. Talk to your doctor right away if you become pregnant while using Depo-Estradiol.

Depo-Estradiol and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Depo-Estradiol has been detected in human breast milk. Depo-Estradiol can decrease the quality or quantity of breast milk. A choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Depo-Estradiol Usage

Use Depo-Estradiol exactly as prescribed.

Depo-Estradiol is available in an injectable form to be given directly into a muscle (IM) by a healthcare professional.

Depo-Estradiol Dosage

Use  this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication

The recommended dose range of Depo-Estradiol (estradiol cypionate) intramuscular injection for the treatment of menopause symptoms is 1 to 5 mg injected every 3 to 4 weeks.

The recommended dose range of Depo-Estradiol (estradiol cypionate) intramuscular injection for the treatment of female hypoestrogenism due to hypogonadism 1.5 to 2 mg injected at monthly intervals.

 

Depo-Estradiol Overdose

If Depo-Estradiol is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Depo-Estradiol FDA Warning

WARNING: ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER.

CLOSE CLINICAL SURVEILLANCE OF ALL WOMEN TAKING ESTROGENS IS IMPORTANT. ADEQUATE DIAGNOSTIC MEASURES, INCLUDING ENDOMETRIAL SAMPLING WHEN INDICATED, SHOULD BE UNDERTAKEN TO RULE OUT MALIGNANCY IN ALL CASES OF UNDIAGNOSED PERSISTENT OR RECURRING ABNORMAL VAGINAL BLEEDING. THERE IS CURRENTLY NO EVIDENCE THAT THE USE OF “NATURAL” ESTROGENS RESULTS IN A DIFFERENT ENDOMETRIAL RISK PROFILE THAN SYNTHETIC ESTROGENS OF EQUIVALENT ESTROGEN DOSE.

CARDIOVASCULAR AND OTHER RISKS 

ESTROGENS WITH AND WITHOUT PROGESTINS SHOULD NOT BE USED FOR THE PREVENTION OF CARDIOVASCULAR DISEASE OR DEMENTIA.

THE WOMEN’S HEALTH INITIATIVE (WHI) STUDY REPORTED INCREASED RISKS OF MYOCARDIAL INFARCTION, STROKE, INVASIVE BREAST CANCER, PULMONARY EMBOLI, AND DEEP VEIN THROMBOSIS IN POSTMENOPAUSAL WOMEN (50 TO 79 YEARS OF AGE) DURING 5 YEARS OF TREATMENT WITH ORAL CONJUGATED ESTROGENS (CE 0.625 MG) COMBINED WITH MEDROXYPROGESTERONE ACETATE (MPA 2.5 MG) RELATIVE TO PLACEBO.

THE WOMEN’S HEALTH INITIATIVE MEMORY STUDY (WHIMS), A SUBSTUDY OF WHI, REPORTED INCREASED RISK OF DEVELOPING PROBABLE DEMENTIA IN POSTMENOPAUSAL WOMEN 65 YEARS OF AGE OR OLDER DURING 4 YEARS OF TREATMENT WITH ORAL CONJUGATED ESTROGENS PLUS MEDROXYPROGESTERONE ACETATE RELATIVE TO PLACEBO. IT IS UNKNOWN WHETHER THIS FINDING APPLIES TO YOUNGER POSTMENOPAUSAL WOMEN.

OTHER DOSES OF ORAL CONJUGATED ESTROGENS WITH MEDROXYPROGESTERONE ACETATE, AND OTHER COMBINATIONS AND DOSAGE FORMS OF ESTROGENS AND PROGESTINS WERE NOT STUDIED IN THE WHI CLINICAL TRIALS AND, IN THE ABSENCE OF COMPARABLE DATA, THESE RISKS SHOULD BE ASSUMED TO BE SIMILAR. BECAUSE OF THESE RISKS, ESTROGENS WITH OR WITHOUT PROGESTINS SHOULD BE PRESCRIBED AT THE LOWEST EFFECTIVE DOSES AND FOR THE SHORTEST DURATION CONSISTENT WITH TREATMENT GOALS AND RISKS FOR THE INDIVIDUAL WOMAN.